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drug discovery

A picture of Urmila Sehrawat, a postdoctoral researcher at Memorial Sloan Kettering Cancer Center.

Postdoc Portrait: Urmila Sehrawat Targets Protein Synthesis in Cancer

Scaling Cell Therapy Manufacturing From Research to GMP

Advancing Gene-Edited Stem Cell Therapy for Friedreich's Ataxia

Automated multi-channel pipette dispensing clear liquid into a 96-well plate for rapid sterility testing.

Sterility in Three Hours, Without the Cutoff Compromise

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Taking Therapeutics from Concept to Clinic

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Researchers Reflect on the Lasting Impact of Science’s Landmark Discoveries

A tablet displaying patient data graphs alongside printed medical charts, a stethoscope, and a laptop.

Rethinking Clinical Trials with Synthetic Control Arms

A multi-colored image of a midbrain organoid is shown on a black background.

How Automation and AI Are Transforming Organoid Research

View of brown folders, with focus on grants label, signifying NIH funding that is pushing against relying solely on animal models.

NIH Signals a Shift Away from Animal Testing With $150M Investment

Circular white pills are shown spilling out of a green medicine bottle on a bright yellow-orange background. A magnifying glass is placed over the pills, indicating drug regulators’ inspection process for new drugs.

Drug Regulation: Science’s Imperfect Art

Conceptual image of blue antibody molecules on a dark background.

Exploring a Lab-in-the-Loop System for Antibody Design

Twist Bio 
A protein structure of Human serum albumin is shown. It has three domains colored in blue, pink, and purple. Amino acid side chains are shown coming off of the protein.

The Rhythms of Life: Tiny Vibrations Reveal How Proteins Move

A vector illustration showing a human head silhouette with a network around a capsule pill, representing AI-designed drugs and healthcare technology.

The Translatability Gap: Why AI Breakthroughs Stall at the Clinic

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A drawing of men and women holding boxes, resigning en mass from their jobs as editors.

Editors Mass Resign from Elsevier Journal After Editor-in-Chief Let Go

A team of cartoon scientists studying a giant pancreas.

Prolonged GLP-1 Exposure Remodels Gene Expression in the Pancreas by Flipping a Molecular Switch

In the TS 40th Anniversary template, Sarkis Mazmanian smiles in a black and white headshot photo on the left. In a photo on the right, he stands in front of a large image of a cross-section of the brain. He wears a navy jacket, a white shirt, and glasses.

Then and Now: Sarkis Mazmanian Finds Gut-Brain Links to Parkinson’s Disease

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Steps to Improve Sustainable Laboratory Practices

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Multimedia

Essential Genes Are Dominantly Activated by Single Transcription Factors

Essential Genes Are Dominantly Activated by Single Transcription Factors

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Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Rethinking ALS Biomarkers: From Discovery to Clinical Impact

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The Scientist Digest cover September 2026
September 2026

Multiplex Microscopy Becomes Easier with Encoded Antibodies

A new system that enables researchers to uniquely tag monoclonal antibodies for use in microscopy could help simplify complex imaging studies.

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Essential Genes Are Dominantly Activated by Single Transcription Factors

Essential Genes Are Dominantly Activated by Single Transcription Factors

EpiCypher Logo
Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Alamar Biosciences logo
Engineering CAR-Neutrophils In Vivo to Target Glioblastoma

Engineering CAR-Neutrophils In Vivo to Target Glioblastoma

Miltenyi
Best Practices for qPCR Assay Design and Optimization

Best Practices for qPCR Assay Design and Optimization

Bio-Rad

Products

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The ASSIST PLUS pipetting robot for affordable workflow automation

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Single cells in suspension

Rapidly isolate primary cells and make uniform single-cell suspensions with Corning® Cell Strainers

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Abstract image representing cell membranes linked together.

CellBrite® Steady Membrane Stain: Cell surface staining built for real-time imaging

Biotium
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Monod Bio Licenses AI-designed Protein Technologies to SignalChem Biotech for Custom Discovery Assays