emulsion PCR, microbiology, cell & molecular biology
Yvonne Saenger: Immunotherapy Pioneer
Yvonne Saenger: Immunotherapy Pioneer
Jef Akst | Apr 1, 2015
Assistant Professor, Department of Medicine, Columbia University. Age: 41
Manipulative Microbiomes
Manipulative Microbiomes
Jenny Rood | Apr 1, 2015
Gut bacteria control tumor growth via the mammalian immune system.
Signaling Resistance
Signaling Resistance
Jenny Rood | Apr 1, 2015
Activating signaling pathways, rather than individual genes, reveals roles for both growth and dedifferentiation in establishing resistance to cancer treatments.
Toggling Between Life and Death
Toggling Between Life and Death
Ashley P. Taylor | Apr 1, 2015
In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.
Setbacks and Great Leaps
Setbacks and Great Leaps
Sue Armstrong | Apr 1, 2015
The tale of p53, a widely studied tumor suppressor gene, illustrates the inventiveness of researchers who turn mishaps into discoveries.
Getting Your Sugar Fix
Getting Your Sugar Fix
Kate Yandell | Apr 1, 2015
A guide to glycan microarrays
Control ALT, Delete Cancer
Control ALT, Delete Cancer
Haroldo Silva, David Halvorsen, Jeremy D. Henson | Apr 1, 2015
Treating cancer by shutting down the alternative lengthening of telomeres (ALT) pathway
Cancer Kismet
Cancer Kismet
Jenny Rood | Apr 1, 2015
Fate mapping allows researchers to follow cancer progression from its cell type of origin.
Cancer Immunotherapist
Cancer Immunotherapist
Jef Akst | Apr 1, 2015
Scientist to Watch Yvonne Saenger explains recent advances in using biomarkers to identify cancer patients who might benefit most from immunotherapy.
Book Excerpt from <em>p53</em>
Book Excerpt from p53
Sue Armstrong | Apr 1, 2015
In Chapter 12, "Of Mice and Men," author Sue Armstrong recounts the point at which researchers moved from working with p53 in tissue culture to studying the gene in animal models.