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Medical illustration of a scientist replacing part of a DNA molecule with tweezers, representing genome editing.
On the Hunt for the Next Breakthrough in Motor Neuron Disease
Deanna MacNeil, PhD | May 9, 2023 | 3 min read
Researchers leave no stone unturned in the search for a spinal muscular atrophy treatment strategy that uses base editing.
Composition of DNA with a glitch effect
“Silent” Mutations Make Noise In Cancer
Katarina Zimmer | May 1, 2023 | 10+ min read
Synonymous mutations have long been ignored in cancer studies since they don’t affect the amino acid sequences of proteins. But research increasingly reveals that they can have disease-driving effects.
David Liu
Targeting a Genetic Accident to Treat Disease
Deanna MacNeil, PhD | 2 min read
David Liu shares how integrating chemistry and evolution in his research has directed his work on base editing techniques aimed at developing new therapeutics.
Image showing recombinant DNA
A Sticky Situation: Recombinant DNA Technology
Kathryn Loydall, PhD | May 1, 2023 | 5 min read
Janet Mertz’s work with simian virus 40 DNA during her graduate years was pivotal for developing DNA recombination as we now know it.
Cas9 enzyme
Molecular Glue ‘Shreds’ Cas9 and Enables a New Form of CRISPR Control
Ida Emilie Steinmark, PhD | Apr 26, 2023 | 3 min read
In a bid to address safety concerns about immune reactions during treatment with CRISPR-based therapeutics, a new technique speeds up how quickly the body destroys the DNA-cutting enzyme Cas9.
Layered visual representation of multiomics
Integrate and Innovate with NGS and Multiomics
The Scientist’s Creative Services Team and Illumina | 6 min read
Researchers across disciplines combine layers of discovery obtained with accessible NGS-based multiomics approaches.
Artist’s rendition of orange DNA coiled around a blue histone protein.
“Cryptic Transcription”: How Aging Cells Express Fragments of Genes
Kamal Nahas, PhD | Apr 6, 2023 | 4 min read
Aging cells with weakened gene regulation spuriously transcribe RNAs, but their impact on health and longevity still needs to be examined.
close-up of X chromosomes
Probing “Selfish” Centromeres Unveils an Evolutionary Arms Race
Michael Lampson, PhD | Apr 3, 2023 | 10 min read
A more complete understanding of nonrandom segregation will shed light on how speciation occurs.
PCR setup thumbnail
Important Players for a Successful PCR
The Scientist’s Creative Services Team and MilliporeSigma | 1 min read
Learn about other PCR components—beyond the polymerase—that are essential for optimal results.
Infographic depicting one way centromeres can "cheat" during meiosis
Infographic: How “Selfish” Centromeres Alter Inheritance
Michael Lampson, PhD | Apr 3, 2023 | 2 min read
Research on so-called selfish genetic loci is providing scientists with greater insight into the biology of chromosome segregation and inheritance.
Artist’s rendition of red SARS-CoV-2 coronaviruses floating near blue strands of DNA.
COVID-19 Infections May Reshape Genetic Landscape
Holly Barker, PhD | Mar 30, 2023 | 3 min read
SARS-CoV-2 infection triggers structural changes in the host cell’s DNA, which provide a molecular explanation for long COVID, a new study suggests. 
Single Cell Sequencing in a Nutshell
Single Cell Sequencing in a Nutshell
Niki Spahich, PhD | 4 min read
By exploring the inner workings of individual cells, rather than averaging bulk populations, researchers identify rare and important cell subtypes.
electron micrograph of grey cancer cell, with two red T cells stuck to the side
Translation of “Jumping Genes” Creates Cancer Therapy Targets
Natalia Mesa, PhD | Mar 29, 2023 | 4 min read
Researchers find many tumor-specific antigens form when cancer genes and transposable elements link up.
A normal human liver organoid (left) stained with blue and red next to a fatty liver organoid (right) with lipid droplets stained yellow.
Working Together to Battle Fatty Liver Disorders
Niki Spahich, PhD | Mar 24, 2023 | 6 min read
Benedetta Artegiani and Delilah Hendriks are forming a joint laboratory group to understand disease mechanisms and treatments through organoid models.
Improve qPCR Efficiency and Reproducibility
The Components of Effective qPCR
Bio-Rad | 1 min read
Putting the pieces together for molecular diagnostics and infectious disease research
Black and white portrait of Paul Berg
‘Godfather of Genetic Engineering’ Paul Berg Dies at 96
Lisa Winter | Mar 23, 2023 | 3 min read
Berg was awarded one-half of the Nobel Prize in Chemistry in 1980 for his work with recombinant DNA technology. 
Copepod (Zooplankton) are a group of small crustaceans found in the marine and freshwater habitat.
Combining Climate Stressors Leads to Unique Changes in the Genome
Jennifer Zieba, PhD | Mar 20, 2023 | 3 min read
Researchers found that copepod genomes adapt in distinct ways when simultaneously exposed to multiple environmental conditions.
TSS
Genomes Across the Tree of Life
The Scientist’s Creative Services Team | 2 min read
Researchers turn to unique eukaryotes to better understand how DNA is organized in 3D space.
Healthcare and medicine, Doctor touch and diagnose a virtual Human Lungs with Covid-19 or coronavirus spread inside on modern interface screen on laboratory, Innovation and Medical technology.
Uncovering Rare Disease Genetic Pathways with Global Biobanks
Deanna MacNeil, PhD | Mar 20, 2023 | 3 min read
Researchers discover new idiopathic pulmonary fibrosis risk factors with multi-ancestry analyses that increase representation of understudied populations.
Fluorescent image of breast tissue
Hormone Therapy Triggers Male Gene Patterns in Transgender Men’s Cells
Holly Barker, PhD | Mar 15, 2023 | 3 min read
A study deepens the scientific understanding of how androgens influence breast tissue, which may offer clues to treating breast cancer. 
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