3D rendering of a scanning electron micrograph of pink malignant cancer cells against a black background
Cancers Ramp Up Overall mRNA Expression as They Progress
Dan Robitzski | Jun 14, 2022
A technique for quantifying tumor mRNA production from messy tissue sample data uncovers an unexpected correlation between it and disease stage in 15 cancer types.
illustration of a branching neuron
Different Forms of Autism Have Opposite Problems with Brain Precursor Cells
Charles Choi | Jun 13, 2022
Compared with cells taken from non-autistic controls, neural precursors from autistic boys proliferated in atypical ways, a small study finds.
Setting High Standards for Antibody Production Using Nucleosomes
Setting High Standards for Antibody Production Using Nucleosomes
Fortis Life Sciences | Jun 20, 2022
A unique approach to antibody production that exposes antibody candidates to nucleosomes is revolutionizing best practices.
Two prime editing guide RNAs (pegRNAs), deliver Cas9 enzymes to targeted regions of the genome.
Infographic: Two Guide RNAs Make for Large, Stable Insertions
Dan Robitzski | Jun 13, 2022
A new technique goes beyond CRISPR and writes two complementary strands of DNA directly into the genome.
Genetic Syndrome and Genetic Disorder, 3D illustration of science concept.
With Two RNA Guides, Editing Technique Writes Long DNA Insertions
Dan Robitzski | Jun 13, 2022
The approach, called GRAND, uses a second guide RNA to write complementary strands of DNA in targeted genomic locations, resulting in efficient insertions that can be hundreds of base pairs long.
Harnessing Stem Cells to Treat Disease
Harnessing Stem Cells to Treat Disease
The Scientist Creative Services Team | Jun 3, 2022
In this webinar, Kim Vanuytsel and Ryan Flannigan will discuss cutting-edge technologies for improving stem cell-based therapies.
Ribonucleic acid strands consisting of nucleotides important for protein bio-synthesis
Katharina Höfer Probes the Machinery of Bacterial Gene Expression
Hannah Thomasy | Jun 13, 2022
The molecular biologist studies how chemical modifications to RNA building blocks change the way RNA regulates complex cellular processes.
Ribbon weed meadow in Shark Bay, Western Australia
World’s Largest Organism Discovered Underwater
Andy Carstens | Jun 2, 2022
Off the western Australian coast, in Shark Bay, a field of seagrass big enough to cover Washington, DC, has flourished for more than four millennia, a new study finds.
Smarter Sample Prep for Improved Single-Cell Sequencing
Smarter Sample Prep for Single-Cell Sequencing
The Scientist Creative Services Team | Jun 1, 2022
In this webinar, Carina Emery will discuss tissue dissociation techniques that lead to high-quality sequencing results.
multicolor DNA sequencing gel
Genetic Mutations Can Be Benign or Cancerous—a New Method to Differentiate Between Them Could Lead to Better Treatments
Ryan Layer | May 27, 2022
Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.
A drawing portraying the black silhouette of Pompeii buildings with Mount Vesuvius and the sky behind them
First Human Genome Sequenced from Ancient Pompeii
Alejandra Manjarrez | May 26, 2022
The genome is from a male who was likely in his late thirties when the historic Mount Vesuvius eruption occurred. The analyses suggest he is related to the diverse Imperial Roman population of the time, and that he may have suffered from spinal tuberculosis.
Technique Talk: Understanding Cancer One Base Edit at a Time
Technique Talk: Understanding Cancer One Base Edit at a Time
The Scientist Creative Services Team | May 19, 2022
Francisco J. Sánchez-Rivera will discuss strategies to design CRISPR base editor libraries for in vivo applications.
a giant isopod in an aquarium
Genome Spotlight: Giant Isopod (Bathynomus jamesi)
Christie Wilcox | May 26, 2022
The first high-quality genome for a marine isopod may shed light on how this group of crustaceans adapted to the deep, dark depths of the ocean.
A cockroach clings to the inside of a white mug.
Injecting Cockroaches with CRISPR Gene Edits Their Offspring
Sophie Fessl | May 25, 2022
A new method has allowed researchers to conduct the first gene knock-out and knock-in edits on cockroaches and may extend to many other insects.
The Future of Cancer Diagnosis with Nanopore Sequencing Technology
The Potential of Nanopore Sequencing Technology in Cancer Diagnosis
The Scientist Creative Services Team | May 11, 2022
In this webinar, Mashiat Mimosa will discuss the potential of a new sequencing method that detects glioma tumors in brain tissue.
Illustration of blue shiny mitochondria
Worms Live Longer with Mitochondria Powered by Light: Preprint
Alejandra Manjarrez | May 24, 2022
Increasing mitochondrial activity in worms by engineering a light-activated proton pump into the organelle’s membrane extends the animals’ lifespan without evidence of health decline, according to a preprint.
Alcohol bottles at a bar
Epigenome Editing Decreases Alcohol Seeking and Anxiety in Rats
Natalia Mesa | May 20, 2022
A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.
MULTI-seq: Single-Cell Genomic Sample Multiplexing Using Lipid-Tagged Indices
MULTI-seq: Single-Cell Genomic Sample Multiplexing Using Lipid-Tagged Indices
The Scientist Creative Services Team | May 9, 2022
In this webinar, Chris McGinnis and Jennifer Silverman discuss how MULTI-seq offers improved sample throughput and data quality.
illustration of purple mitochondrion within a cell
Rogue Mitochondria Turn Hermaphroditic Snails Female: Study
Patience Asanga | May 19, 2022
The accidental finding marks the first time a phenomenon called cytoplasmic sterility, known to occur in plants, has been found in animals.
A drawing of pseudostratified gut epithelial cells in the early intestines, cells in red and nucleus in purple.
Move Over Apoptosis: Another Form of Cell Death May Occur in the Gut
Natalia Mesa | May 18, 2022
Though scientists don’t yet know much about it, a newly described process called erebosis might have profound implications for how the gut maintains itself.