Signaling Dynamics Fine-Tune Gene Expression
Signaling Dynamics Fine-Tune Gene Expression
Ruth Williams | Sep 3, 2021
The dynamic behavior of a transcriptional activator can be used to specify the activity level of its target gene, a study suggests.
Infographic: A Yeast Model for Studying Histone Modifications
Infographic: A Yeast Model for Studying Histone Modifications
Amanda Heidt | Sep 1, 2021
The methodology involves modifying histones and displaying them on the cell surface for analysis.
When Researchers Sound the Alarm on Problematic Papers
When Researchers Sound the Alarm on Problematic Papers
Shawna Williams | Sep 1, 2021
Finding and reporting an irregularity in a published study can lead people down an unexpected path.
Yeast “Mini Labs” Help Researchers Probe Histone Modifications
Yeast “Mini Labs” Help Researchers Probe Histone Modifications
Amanda Heidt | Sep 1, 2021
By harnessing a unique property of yeast, scientists can synthesize histones and the enzymes that modify these proteins, which spool DNA and influence gene expression.
Mechanosensory Protein Helps Tendons Stiffen After Exercise
Mechanosensory Protein Helps Tendons Stiffen After Exercise
Catherine Offord | Sep 1, 2021
Researchers identify a role for PIEZO1 in tendon adaptation, and show that people with certain versions of the Piezo1 gene tend to be better jumpers.
Opinion: The Pandemic and the RNA Sequencing Gap
Opinion: The Pandemic and the RNA Sequencing Gap
Robert Ross | Sep 1, 2021
RNA sequencing technology lags far behind researchers’ ability to decode and understand DNA. The COVID-19 pandemic has highlighted this dangerous shortcoming.
7,200-Year-Old Skeleton Offers Clues to Early Human Migration
7,200-Year-Old Skeleton Offers Clues to Early Human Migration
Catherine Offord | Aug 29, 2021
Analysis of DNA from remains found in an Indonesian cave provides new insight into human movements among the islands between East Asia and Australia.
Genes for Alcohol Use Disorder and Alzheimer’s Risk Overlap: Study
Genes for Alcohol Use Disorder and Alzheimer’s Risk Overlap: Study
Emma Yasinski | Aug 24, 2021
Genetic, transcriptomic, and epigenetic data reveal molecular mechanisms tying these disorders to each other and to immune disfunction.
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Abby Olena | Aug 18, 2021
RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.
Indigenous Filipino Group Has Highest Known Denisovan Ancestry
Indigenous Filipino Group Has Highest Known Denisovan Ancestry
Annie Melchor | Aug 13, 2021
Researchers found the relatively high proportion of DNA from a hominin cousin—nearly 5 percent—when they scanned more than 1,000 genomes from 118 distinct ethnic groups.
The Extinct Species Within
The Extinct Species Within
Christie Wilcox | Aug 6, 2021
The genomes of living animals are littered with DNA from long-gone relatives, providing a lens on evolution, past extinctions, and perhaps even solutions to agricultural problems.
Noncoding RNA Improves Symptoms in Mice with Metabolic Disorder
Noncoding RNA Improves Symptoms in Mice with Metabolic Disorder
Abby Olena | Aug 6, 2021
A long noncoding RNA from humans appeared to help the enzyme phenylalanine hydroxylase work better in a mouse model of phenylketonuria, the disorder characterized by reduced activity of that enzyme.
Freeze-Dried Mouse Sperm Sent by Postcard Produces Baby Mice
Freeze-Dried Mouse Sperm Sent by Postcard Produces Baby Mice
Amanda Heidt | Aug 5, 2021
Rather than relying on samples that need to be shipped in glass vials and on ice, researchers have developed a new method that allows mouse sperm to be sent easily at room temperature using standard mail delivery.
Book excerpt from <em>CRISPR People</em>
Book excerpt from CRISPR People
Henry T. Greely | Aug 1, 2021
In Chapter 6, author Henry T. Greely describes how news of the birth of gene-edited babies rocked a 2018 summit on human genome editing.