genetics

A technique for quantifying tumor mRNA production from messy tissue sample data uncovers an unexpected correlation between it and disease stage in 15 cancer types.

Compared with cells taken from non-autistic controls, neural precursors from autistic boys proliferated in atypical ways, a small study finds.

A new technique goes beyond CRISPR and writes two complementary strands of DNA directly into the genome.

The approach, called GRAND, uses a second guide RNA to write complementary strands of DNA in targeted genomic locations, resulting in efficient insertions that can be hundreds of base pairs long.

The molecular biologist studies how chemical modifications to RNA building blocks change the way RNA regulates complex cellular processes.

Off the western Australian coast, in Shark Bay, a field of seagrass big enough to cover Washington, DC, has flourished for more than four millennia, a new study finds.

Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.

The genome is from a male who was likely in his late thirties when the historic Mount Vesuvius eruption occurred. The analyses suggest he is related to the diverse Imperial Roman population of the time, and that he may have suffered from spinal tuberculosis.

The first high-quality genome for a marine isopod may shed light on how this group of crustaceans adapted to the deep, dark depths of the ocean.

A new method has allowed researchers to conduct the first gene knock-out and knock-in edits on cockroaches and may extend to many other insects.

Increasing mitochondrial activity in worms by engineering a light-activated proton pump into the organelle’s membrane extends the animals’ lifespan without evidence of health decline, according to a preprint.

A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.

The accidental finding marks the first time a phenomenon called cytoplasmic sterility, known to occur in plants, has been found in animals.

Though scientists don’t yet know much about it, a newly described process called erebosis might have profound implications for how the gut maintains itself.