A circle containing many smaller shapes surrounded by circles containing a single abstract shape.
Building Cells from the Bottom Up
Danielle Gerhard, PhD | Jun 14, 2024 | 8 min read
To understand the molecular blueprint for life, Cees Dekker is starting from scratch, building fully synthetic cells that are capable of cell division.
Image of Alison Van Eenennaam holding a black calf in her arms as they pose for the camera.
Herding Innovation in Livestock
Laura Tran, PhD | Jun 14, 2024 | 9 min read
Alison Van Eenennaam uses genome-editing technologies to aid beef cattle production and animal welfare.
Understanding the Effects of Extrachromosomal DNA on Cancer
The Scientist | 1 min read
Lukas Chavez uses multiomic techniques to study how extrachromosomal DNA (ecDNA) contributes to tumor heterogeneity and gene expression changes in medulloblastoma.
3D cubes showing letters representing the four DNA bases (adenine, guanine, cytosine, and thymine) and small DNA helices.
Discovering the Functions of Noncoding Sequence Variants
Niki Spahich, PhD | Jun 12, 2024 | 4 min read
Neville Sanjana explored noncoding genomic regions by combining pooled CRISPR screening and single cell sequencing.
A light blue circular double helix against a dark blue background.
Artificial Chromosomes for Disease Modeling
Holly Barker, PhD | Jun 12, 2024 | 3 min read
A new technique for synthesizing chromosomes can introduce panels of genes into disease models to facilitate drug testing.
A DNA strand and a barcode representing the DNA barcoding technique.
DNA Barcoding: Species Detection and High Throughput Assays
Priyom Bose, PhD | 7 min read
DNA barcoding is a fast sequencing-based technique that scientists use to catalog all life on Earth or perform high throughput bioanalyses.
Graphic depicting the microbiota consisting of various blue and red bacterial cells
Boosting Bacterial Genomes to Better Explore the Microbiome
Aparna Nathan, PhD | Jun 7, 2024 | 4 min read
Gang Fang’s new metagenomics method helps sequence rare bacteria.
Cartoon of clock faces arranged in the shape of a brain.
Human Neurons Play the Waiting Game
Shelby Bradford, PhD | Jun 5, 2024 | 4 min read
When it comes to development, an epigenetic clock may be responsible for human neurons’ slower maturation.
Willow warbler (Phylloscopus trochilus) perched on a branch with its wings extended.
Two Genetic Loci Control Migration Direction in a Small Bird Species
Pedro Andrade, PhD | 4 min read
The innate genetic program that controls migratory behavior in birds is shrouded in mystery, but scientists are closer to understanding how genetic variation influences their routes between Europe and Africa.
Image of retinal organoid showing blue cones in cyan and green/red cones in green. Rod cells are marked in magenta.
Cracking the Color Cone-undrum in Human Vision
Laura Tran, PhD | Jun 3, 2024 | 2 min read
Cell color perception fates are determined by a signaling mechanism, not chance, during retinal development.
Small <em >Arabidopsis</em> seedlings are grown indoors.
Bioengineering Interkingdom Communication
Hannah Thomasy, PhD | Jun 3, 2024 | 2 min read
Genetically edited bacteria sense the environment and report their findings to “listening” plants.
Three dividing <em >Epulopiscium viviparus</em> cells seen on a microscope.
The Genome of a Gigantic Bacterium Reveals Odd Metabolic Properties
Megan Keller | 4 min read
With its complete genome sequenced, one of the world’s largest microbes harbors unique energy processes that highlight its relation to its symbiotic host, the surgeonfish.
A 3D spherical neutrophil animation with a pink, polysegmented nucleus
The Nucleus’ Secret to Shapeshifting
Kamal Nahas, PhD | May 31, 2024 | 4 min read
Neutrophils contort their nuclei into various shapes by moderating one key regulatory protein previously shown to orchestrate DNA organization.
Several X-shaped duplicated chromosomes floating on a blurry blue background.
Centromeres Mutate More Rapidly Than Expected
Kamal Nahas, PhD | May 30, 2024 | 4 min read
After sequencing centromeres in humans and other primates, researchers found that they vary greatly across species and potentially contribute to aging and disease.
Molecular illustration of CRISPR editing the DNA double helix
Prime Time Precision with CRISPR Technologies
The Scientist | 1 min read
Base editors and prime editors help researchers perform more precise in vivo and ex vivo translational research.
A Hydractinia polyp with stinging cells shown in red throughout the body and the tentacles.
With Neither Brains nor Brawn, Jellyfish and Relatives Developed Subcellular Weapons Instead
Hannah Thomasy, PhD | May 29, 2024 | 6 min read
Anna Klompen explained how cnidarian stinging cells harpooned their way into her heart and could help answer fundamental questions in biology.
Brown and black flat-coated retrievers sit on a path in the woods.
Obesity Research is Going to the Dogs
Hannah Thomasy, PhD | May 27, 2024 | 5 min read
Gene mutations in rotund retrievers shed light on the neural regulation of body weight.
An illustration of multicolored DNA bands on a gel after Sanger sequencing.
The Sequencing Revolution
The Scientist | 1 min read
Learn how cutting-edge sequencing techniques accelerate basic and disease research.
Image of a stem cell and DNA against a light background.
Using Genetic Cartography to Map Cell Lineage
Laura Tran, PhD | May 17, 2024 | 4 min read
By coupling cell lineage tracking with molecular gene expression patterns, researchers deciphered how gene activity influences immune cell production.
Image of three chromosomes &quot;trees&quot; with the highlighted section displaying telomeres shortening over time as &ldquo;falling leaves&rdquo;.
Chromosome Ends in Double Jeopardy
Laura Tran, PhD | May 16, 2024 | 4 min read
Researchers have finally uncovered the other half of the end-replication problem at the lagging strand.