Close up on eyes of mother and daughter faces next to one another
A Long and Unhealthy Life?
Aparna Nathan, PhD | Sep 13, 2023 | 3 min read
A new mouse model shows that the Myc protein has complex effects on aging and cancer.
Professor Sir Ian Wilmut with Dolly the sheep
Ian Wilmut, Famed Scientist Who Led the Creation of Dolly the Sheep, Died at 79
Shelby Bradford, PhD | Sep 12, 2023 | 3 min read
Knighted in 2008, Sir Ian Wilmut revolutionized the field of cloning, stem cell research, and regenerative medicine.
Journal club logo on purple background
The Scientist's Journal Club: Transcriptomics
The Scientist’s Creative Services Team | 2 min read
Scientists discuss their latest findings on immune cell dynamics, neurodegenerative disease risk factors, and rare cell types obtained from bulk and single cell RNA sequencing experiments.
Image of spatial transcriptomic spots superimposed onto a stained tissue section.
Poor Cancer Prognosis Associated with a Transcriptional Signature
Charlene Lancaster, PhD | Sep 11, 2023 | 4 min read
Researchers connect a tumor’s leading edge transcriptional profile to poor survival outcomes across cancer types. 
An elderly person in beige shirt and a knitted, cream-colored vest holds a wooden walking stick.
New Epigenetic Clocks May Confirm Extreme Age
Ida Emilie Steinmark, PhD | Sep 8, 2023 | 4 min read
How will a new version of epigenetic clocks aimed at validating the age of people older than 100 years of age balance accuracy and anonymity?
Team of Medical Research Scientists Collectively Working on a New Generation Experimental Drug Treatment. Laboratory Looks Busy, Bright and Modern.
Next-Generation Sequencing: A World without Limits
The Scientist’s Creative Services Team and Illumina | 5 min read
Centralized core facilities and commercial service providers specializing in NGS provide expertise and training for researchers new to the method.
A computer-generated image of chromosomes on a black background. One chromosome has a ring of bright orange to indicate a mutation.
Prime Editing Comes of Age
Ida Emilie Steinmark, PhD | Sep 8, 2023 | 9 min read
Since the technique was first published in 2019, prime editing has grown with lightning speed, alongside hopes for what it can achieve.
A man sitting at a desk in a white lab coat holds up a large model of a <em >Drosophila</em> fly. In the background is a window and a bookcase.
The Origins and Recent Promise of Nonsense Suppressor tRNAs
Ida Emilie Steinmark, PhD | Sep 8, 2023 | 4 min read
A discovery that goes back to the first studies of translation has become the topic of biotech buzz.
Discover how a cellphone-driven UV gel documentation system accelerates accessible imaging.
Accessible Gel Imaging with a Cellphone
Analytik Jena | 1 min read
In the classroom or the laboratory, a new gel documentation system enables scientists to capture snapshots of their samples in real time.
The prime editing machinery comprises a prime editing guide RNA (pegRNA) and a Cas9 nickase enzyme fused to a reverse transcriptase.
Infographic: How Prime Editing Works
Ida Emilie Steinmark, PhD | Sep 8, 2023 | 4 min read
Prime editing is one of the most promising forms of genome editing because it uses only single-stranded DNA breaks.
This shows a cryo-EM map of a Fanzor protein in complex with its guiding RNA (in purple) and DNA (target strand in red, complementary strand in blue).
CRISPR-like Abilities in Eukaryotic Proteins
Ida Emilie Steinmark, PhD | Sep 8, 2023 | 4 min read
Two groups independently discovered that Fanzor proteins in eukaryotic organisms are CRISPR’s genome-editing cousins.
How Can Core Labs Help You Get Started with NGS?
The Scientist’s Creative Services Team | 1 min read
Next-generation sequencing (NGS) core facility scientists and researchers new to NGS discuss their fruitful collaborations, highlighting how to receive expert help from genomics facilities.
A photo of the PlatinumTM Next-Generation Protein Sequencer, a small roughly cube-shaped blue-black-silver instrument.
Breaking Down Barriers to Protein Sequencing
The Scientist Staff | Sep 1, 2023 | 2 min read
Next-generation protein sequencing is becoming more powerful, streamlined, and accessible. 
Oops, speech bubble.
The Oligo Was a No Go
Danielle Gerhard, PhD | Sep 1, 2023 | 2 min read
As soon as Melanie McConnell added the wash buffer to her sample, she knew she had made a mistake.
Discover Targeted DNA Sequencing
Targeted DNA Sequencing: Probing for Answers
The Scientist’s Creative Services Team and Roche | 1 min read
A more focused investigation for more in-depth answers.
This is an image of a bioluminescent from gene expression reporter in stem cells from a rhinoceros.
A Stem Cell Zoo Reveals Surprising Differences in Embryogenesis
Ida Emilie Steinmark, PhD | Sep 1, 2023 | 2 min read
By comparing stem cells from six mammals of different sizes, scientists discovered stark differences in embryonic development paces.
The illustration shows floating chromosomes with a Y-shaped chromosome in the foreground.
Closing the Gaps in the Human Genome: Why Y Was the Final Hurdle
Kamal Nahas, PhD | Aug 28, 2023 | 4 min read
For two decades, scientists struggled to fully sequence the Y chromosome. Finally, researchers have mapped its full length thanks to recent advances in sequencing technology.
Introduction to AAV Gene Therapies
Introduction to AAV Gene Therapies
Nicole Stivers, PhD | 4 min read
Small-scale successes in rare disease treatments prime large-scale industry innovations.
A dart board with on dart on the bullseye and several scattered darts that missed the target
Predicting the Next Level of CRISPR Control
Deanna MacNeil, PhD | Aug 28, 2023 | 3 min read
Scientists combine the power of genome-wide screens and machine learning to unlock the secrets of transcriptome engineering with Cas13.
A light gray mouse against an orange background listens to tiny headphones
Journey to the Center of the Ear
Niki Spahich, PhD | Aug 28, 2023 | 5 min read
An aqueduct connecting the brain to the ear may make gene therapy for hearing loss less invasive.