Illustration of a glowing orange DNA double helix with a blurry blue brain in the background.
A Brain Breakthrough 25 Years in the Making
Aparna Nathan, PhD | May 14, 2024 | 5 min read
New sequencing technologies unmask a mutation that sheds new light on ataxia.
The heart sections on the left present defects while the hearts on the right do not show defects. 
Genetic Signatures of a Defective Heart
Mariella Bodemeier Loayza Careaga, PhD | May 14, 2024 | 4 min read
In a mouse model of Down syndrome, three copies of a gene encoding a kinase contributed to congenital heart defects.
Three dividing <em >Epulopiscium viviparus</em> cells seen on a microscope.
The Genome of a Gigantic Bacterium Reveals Odd Metabolic Properties
Megan Keller | 4 min read
With its complete genome sequenced, one of the world’s largest microbes harbors unique energy processes that highlight its relation to its symbiotic host, the surgeonfish.
Cartoon of a turtle inside of an ice cube.
The First Turtle Organoids
Danielle Gerhard, PhD | May 13, 2024 | 5 min read
Herpetology meets hepatology as scientists develop new tools for exploring how turtles survive freezing, oxygen-poor environments.
Light shines through a dilated pupil to illuminate the light red retina, blood vessels, optic disc and macula.
Gut Bacteria Slip into the Eye
Rachael Moeller Gorman | May 9, 2024 | 5 min read
A gene mutation causes porous gut and retinal barriers, allowing bacteria to travel from one to the other, triggering retinal degeneration in mice.
Molecular illustration of CRISPR editing the DNA double helix
Prime Time Precision with CRISPR Technologies
The Scientist | 1 min read
Base editors and prime editors help researchers perform more precise in vivo and ex vivo translational research.
Close-up painting of hands drawing the DNA helix.
Measuring Mutagenesis with Precision Genome Editing
Deanna MacNeil, PhD | May 3, 2024 | 5 min read
A new prime editing sensor library targeting p53 mutations allowed scientists to interrogate thousands of tumor genotypes as they arose in endogenous contexts.
An abstract illustration of a DNA helix and human lungs.
A New Delivery System Offers Hope for Cystic Fibrosis
Charlene Lancaster, PhD | May 1, 2024 | 4 min read
CRISPR-carrying lipid nanoparticles enabled researchers to correct a rare nonsense mutation in the lungs of a cystic fibrosis mouse model.
An illustration of multicolored DNA bands on a gel after Sanger sequencing.
The Sequencing Revolution
The Scientist | 1 min read
Learn how cutting-edge sequencing techniques accelerate basic and disease research.
DNA molecules.
Genetic Imprints in the Brain
Mariella Bodemeier Loayza Careaga, PhD | May 1, 2024 | 2 min read
Neuroscientist Anthony Isles studies how the epigenetic phenomenon of genomic imprinting influences the brain and its functions.
Front view of a blue and red brain animation with a blue background.
One Gene with a Domino Effect on Social Behavior
Kamal Nahas, PhD | Apr 29, 2024 | 4 min read
A transcription factor in mouse brains underpins stress, social behaviors, and possibly immunity.
Researchers can obtain epigenetic information in addition to genetic insights from a single DNA sample.
The Six-Base Genome Reveals Multimodal Data from a Single DNA Sample
The Scientist and biomodal | 4 min read
To gather multiomic insights, researchers used to combine data from multiple workflows, but duet evoC provides more information from less sample in one workflow.
3D illustration of white neurons with projecting dendrites.&nbsp;
Stop the Variant, Save the Channel
Shelby Bradford, PhD | Apr 25, 2024 | 4 min read
By using antisense oligonucleotides to inhibit a mutated exon associated with Timothy syndrome mutation, researchers restored neuron function.
Conceptual 3D rendering of human body consisting of grey strings on blue background.
Ancient Alleles Shed Light on Atherosclerosis Risk
Iris Kulbatski, PhD | Apr 19, 2024 | 5 min read
Calculating the polygenic risk scores of ancient humans such as Ötzi the iceman helps researchers understand the genetic predisposition to cardiovascular disease.
Tapping Into Immunotherapy&rsquo;s Potential to Help More People
Tapping into Immunotherapy’s Potential to Help More People
The Scientist Staff | 2 min read
Discover what researchers have learned about varying immunotherapy response rates between patients with the same cancer types.
Children running through a field.
Aimless Monocytes Underlie a Rare Lung Disease
Niki Spahich, PhD | Apr 18, 2024 | 4 min read
Children with a multifaceted lung disorder share a receptor deficiency, which has implications for monocyte migration into the lungs.
Conceptual illustration of personalized medicine with medical icons next to a human face.
The Largest Whole-genome Sequencing Study in Cancer 
Danielle Gerhard, PhD | Apr 17, 2024 | 7 min read
Comprehensive genome sequencing of 13,880 tumors revealed somatic and germline mutations that could influence patient treatment and prognosis.
Epigenetics in a Dish
The Scientist | 2 min read
Jonathan Weissman and Luke Gilbert share how they developed several CRISPR-based epigenetic editors and how these tools differ from traditional CRISPR.
Grey cloud of smoke on a black background.
After the Smoke Clears: Scars on the Immune System 
Danielle Gerhard, PhD | Apr 15, 2024 | 6 min read
Smoking leaves epigenetic marks on DNA long after cessation, with consequences for adaptive immunity.
Depiction of human DNA helix.&nbsp;
An Epigenetic Strategy to Control Bad Cholesterol
Maggie Chen | Apr 12, 2024 | 3 min read
Modifying markers on DNA allows scientists to lower cholesterol levels in mice, even long-term.