An orange-brown pineapple sea cucumber, covered in wart-like growths, rests on the seafloor in front of some coral, with a school of fish swimming overhead.
How the Sea Cucumber Defends Itself . . . From Itself
Natalia Mesa | Jul 1, 2022
The marine animals have evolved a unique molecular pathway enabling them to use toxins to fight off invaders without poisoning themselves in the process.
A section of a mouse distal colon showing luminal contents with bacteria in magenta, the mucus lining (green) and the epithelial cell barrier of the gut (blue, right).
Mapping the Neighborhoods of the Gut Microbiome
Abby Olena | Jul 1, 2022
Researchers are going beyond fecal samples to understand how the patterns of commensal microbes in the gastrointestinal tract influence development and health.
Overcoming T Cell Therapy Barriers with Engineered Proteins
Overcoming T Cell Therapy Barriers with Engineered Proteins
The Scientist Creative Services Team | Jul 13, 2022
Shannon Oda will discuss how to develop novel engineered fusion proteins to improve T cell therapies against hematological and solid tumors.
Photo taken from the perspective of a lab worker in a white coat and purple gloves preparing multiple fecal transplant capsules at a time.
Banking Previous Poos: Could a Transplant of Feces from Your Past Heal You?
Dan Robitzski | Jun 30, 2022
The Scientist spoke with Brigham and Women’s Hospital and Harvard Medical School researchers Scott Weiss and Yang-Yu Liu, who propose that people bank stool samples when they’re young and healthy so that they can be transplanted to rejuvenate the gut microbiome later on.
Artist’s rendering of aquamarine T cells in front of a blue and green background.
Study Links Stress to a Faster-Aging Immune System
Margaret Osborne | Jun 21, 2022
Health data from 5,744 adults over the age of 50 reveals an association between stressors such as discrimination and a relatively small proportion of younger infection-fighting immune cells.
The Epigenetic Landscape During T Cell Exhaustion
The Epigenetic Landscape During T Cell Exhaustion
The Scientist Creative Services Team, 10x Genomics | Jul 6, 2022
In this webinar, E. John Wherry and Debattama Sen will discuss how epigenetic scarring of exhausted T cells influences chronic infections.
A small, brown mouse runs on a narrow, miniature treadmill
How Exercise Helps Mice Fight Pancreatic Cancer
Dan Robitzski | Jun 15, 2022
A study reveals a molecular pathway linking exercise to an amped-up immune response to pancreatic cancer and greater responsiveness to treatment.
Vaccine illustration 
Infographic: Inducing Active Immunity Against Opioid Overdose
Tori Rodriguez | Jun 13, 2022
How scientists aim to induce an immune response against addictive drugs
spatial CRISPR screen for cancer
A Brave New World for Spatial Genomics in Cancer Research
Nele Haelterman, PhD | Jun 27, 2022
A new CRISPR screening technology allows scientists to recreate tumor heterogeneity in vivo and study how it affects all aspects of cancer biology.
Illustration of a syringe with a person falling out of a bottle of pills
Opioid Vaccines as a Tool to Stem Overdose Deaths
Tori Rodriguez | Jun 13, 2022
Researchers are turning to the immune system for help in treating addiction and preventing overdose.
Spraying spray bottle
Nasal Vaccines Are Commercially High Risk, Perhaps High Reward
Jef Akst | Jun 13, 2022
Dozens of intranasally delivered vaccines targeting SARS-CoV-2 are in development. Could they pave the way for widespread nasal vaccination in the future?
Reinvigorating the Immune System to Attack Cancer Cells Using Highly Specific Antibodies
Reinvigorating the Immune System to Attack Cancer Cells Using Highly Specific Antibodies
Fortis Life Sciences | Jun 20, 2022
Cancer immunotherapy targets the tumor microenvironment, blocking the molecular pathways that tumors exploit to prevent immune cell activity.
animation showing how proximity affects viral transmission
Monkeypox Likely Spread Undetected in US Before Recent Reports  
Andy Carstens | Jun 6, 2022
Two strains of monkeypox have been detected in the US, suggesting the virus has been circulating in the country for some time, the CDC says.
Illustration showing rod-shaped Mycobacterium tuberculosis bacteria in the lungs of a person with tuberculosis
Delayed T cell Response Allows Tuberculosis to Gain Foothold in Monkeys
Anna Napolitano | Jun 1, 2022
The results could help guide the design of new vaccines for the disease.
The Scientist Speaks - To Conserve and Protect: The Quest for Universal Vaccines
Niki Spahich, PhD | May 24, 2022
Patrick Wilson discusses the challenges in designing universal vaccines and his work developing one for influenza.
Microscopic image of nerves in the eye, a pathogen, and t cells
Science Snapshot: Eye Immunity
Lisa Winter | May 26, 2022
Researchers find that tissue-resident memory T cells in the corneas of mice engender a lasting immune response.
Outlines of people in multiple colors
HHMI to Award More than $1 Billion to Promote Equity in Research
Andy Carstens | May 26, 2022
A new program will provide 150 early-career scientists committed to advancing diversity, inclusion, and equity up to $8.6 million each.
Using Single Cell Proteomics to Understand Human Health and Disease
Using Single Cell Proteomics to Understand Human Health and Disease
The Scientist Creative Services Team, 10x Genomics | May 5, 2022
Miriam Merad and Harrison Specht will discuss how single cell proteomics complement other omics methods to provide insight into disease pathophysiology and treatment.
Group of cells stained in either blue or green in a black background.
Diabetes Marker Linked to COVID-19 Severity in Mice
Alejandra Manjarrez | May 16, 2022
A sugar that’s less abundant in the blood of people with diabetes binds to SARS-CoV-2’s spike protein and disrupts the virus’s ability to fuse with cells.  
Senior woman wearing a grey pullover sitting on a bed and holding her back.
Early Inflammation Protects Against Chronic Pain, Study Finds
Alejandra Manjarrez | May 12, 2022
Human data and experiments in mice challenge the common use of anti-inflammatory drugs to treat pain.