This previously unknown mechanism for spotting foreign genetic material in the cytoplasm launches antiviral defenses even when the well-known immune mediator STING is absent.

In mice, the fight-or-flight response overactivates the cells, causing a drop in their numbers, which leads to loss of hair color.

In mice, a group of nasal epithelial cells called brush cells release pro-inflammatory signals in response to allergens.

The Oxford researcher’s work on lipid and peptide antigens revealed key mechanisms in inflammation, immunotherapy, and vaccination, which are being pursued in clinical trial treatments.

Genes related to the immune system stay active throughout the tree’s life.

A newly identified group of viruses may help suppress eukaryotes’ immune response and promote tolerance of endosymbiotic bacteria.

An accumulation of T cells and astrocytes in postmortem brain tissue hints at possible autoimmune origins for many cases of autism.

Recent work in humans and mice highlights how exposure to environmental microbes helps protect against allergies and other inflammatory diseases.

A T cell discovery, “hachimoji” DNA, a new species of human, and mounting fears of espionage rounded off the list this year.