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What Causes Type 2 Diabetes?
Barbara E. Corkey | Jul 1, 2016
Insulin resistance and high levels of insulin and lipids all precede the development of metabolic dysfunction. Which metabolic factor is to blame?
How High Fat and Insulin Levels May Lead to Diabetes
Barbara E. Corkey | Jun 30, 2016
Lipids and insulin play important roles in blood sugar regulation, and altered levels of either could kick start metabolic dysfunction.
Gut Microbiota–Obesity Link Clarified
Catherine Offord | Jun 10, 2016
Changes in diet can cause gut microbes to produce acetate, which in turn stimulates insulin secretion and obesity in rodents, scientists show.
Newly Discovered Hormone Explains Disease
Kerry Grens | Apr 15, 2016
Patients with neonatal progeroid syndrome lack a glucose-releasing hormone, while people with insulin resistance have an abundance.
Insulin-Producing Mini Stomachs
Catherine Offord | Feb 22, 2016
Scientists grow gastric organs in vitro that can restore insulin production when transplanted into mice.
Programming Pancreatic Cells
Catherine Offord | Jan 7, 2016
Researchers reprogram human skin cells to make insulin-producing pancreatic cells that can prevent diabetes in mice.
Prominent Endocrinologist Dies
Karen Zusi | Nov 20, 2015
Guenther Boden, who linked insulin resistance with fatty acids in the blood, has passed away at age 80.
The 6,000-Calorie Diet
Jef Akst | Nov 1, 2015
Overeating and inactivity lead to insulin resistance in just days—and oxidative stress is to blame.
Breaking the Cancer-Obesity Link
Laura W. Bowers, Stephen D. Hursting, Ciara H. O’Flanagan | Nov 1, 2015
Obese people are at higher risk for developing cancer, have worse prognoses once diagnosed, and are often resistant to chemotherapy regimens. The question is, Why?
A Complex Disorder
Stephen D. Hursting, Ciara H. O’Flanagan, Laura W. Bowers | Nov 1, 2015
Factors that likely contribute to obesity include disruptions to intercellular signaling, increased inflammation, and changes to the gut microbiome.