iPSCs, cell & molecular biology, microbiology
Setbacks and Great Leaps
Setbacks and Great Leaps
Sue Armstrong | Apr 1, 2015
The tale of p53, a widely studied tumor suppressor gene, illustrates the inventiveness of researchers who turn mishaps into discoveries.
Toggling Between Life and Death
Toggling Between Life and Death
Ashley P. Taylor | Apr 1, 2015
In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.
Signaling Resistance
Signaling Resistance
Jenny Rood | Apr 1, 2015
Activating signaling pathways, rather than individual genes, reveals roles for both growth and dedifferentiation in establishing resistance to cancer treatments.
Manipulative Microbiomes
Manipulative Microbiomes
Jenny Rood | Apr 1, 2015
Gut bacteria control tumor growth via the mammalian immune system.
Yvonne Saenger: Immunotherapy Pioneer
Yvonne Saenger: Immunotherapy Pioneer
Jef Akst | Apr 1, 2015
Assistant Professor, Department of Medicine, Columbia University. Age: 41
From Many, One
From Many, One
Elena E. Giorgi | Apr 1, 2015
Diverse mammals, including humans, have been found to carry distinct genomes in their cells. What does such genetic chimerism mean for health and disease?
Resisting Cancer
Resisting Cancer
George Klein | Apr 1, 2015
If one out of three people develops cancer, that means two others don’t. Understanding why could lead to insights relevant to prevention and treatment.
Soil Bacteria Live on Wine Grapes
Soil Bacteria Live on Wine Grapes
Kerry Grens | Mar 25, 2015
The earthiness of Merlot may have to do with grapevine-dwelling microbiota.
Short, Strong Signals
Short, Strong Signals
Ruth Williams | Mar 25, 2015
Methylation increases both the activity and instability of the signaling protein Notch.
Quorum-Sensing Molecule Modifies Gut Microbiota
Quorum-Sensing Molecule Modifies Gut Microbiota
Anna Azvolinsky | Mar 19, 2015
Increasing the abundance of a chemical some microbes use to communicate with one another can help reinstate beneficial bacterial populations in the guts of antibiotic-treated mice.