A ball-and-stick plus ribbons molecular model of the hormone orexin, also known as hypocretin, isolated on a white background.
2023 Breakthrough Prizes Showcase Research in AI and Narcolepsy
Amanda Heidt | Sep 22, 2022
Three prizes were awarded to six researchers working across the life sciences on cellular organization, protein structure, and the genetic underpinnings of a chronic sleep disorder.
Woman holding a glass of water in one hand and pill in the other
Daily Multivitamin May Slow Cognitive Decline in Seniors
Andy Carstens | Sep 14, 2022
Researchers caution that it’s too soon to recommend supplements based on the results of a new study.
Motor neurons, undergoing degeneration in ALS
Mutant T Cells That Drive Amyotrophic Lateral Sclerosis (ALS) Progression May React To a Brain Antigen
Nele Haelterman, PhD
Scientists discovered a possibly autoreactive T cell population that forecasts and supports disease progression.
artistic representation of jumping gene
Jumping Genes Can Cause Movement Disorder: Study
Sophie Fessl | Sep 13, 2022
Mice with overactive LINE-1 retrotransposons in their brains exhibit movement difficulties, suggesting the genetic elements may play a role in ataxia in humans. 
Newborn baby rats lie in a basket
Mother’s Circadian Rhythms Mirrored in Fetal Rat Brains
Bianca Nogrady | Sep 12, 2022
Before their own central clocks develop, the brains of fetal rats detect their mother’s metabolic cycle to help regulate the expression of certain genes.
The balance of mind and body on a seesaw
Psychological Stress Distracts the Immune System from Fighting Infections
Jennifer Zieba, PhD
Acute stress makes immune cells migrate immediately to the bone marrow, which prepares the body for injury at the expense of increasing infectious disease susceptibility.
Conceptual image showing molecules making up a brain shape
The Noncoding Regulators of the Brain
Christie Wilcox | Sep 12, 2022
Noncoding RNAs are proving to be critical players in the evolution of brain anatomy and cognitive complexity.
Genetic knockout experiments reveal a role for the protein in forming and maintaining synapses between motor neurons and muscle fibers in mice.
Infographic: Vangl2 in Muscles Keeps Neuromuscular Junctions Organized
Catherine Offord | Sep 12, 2022
Genetic knockout experiments reveal a role for the protein in forming and maintaining synapses between motor neurons and muscle fibers in mice.
Autophagy and Mitophagy in Neurodegeneration: A Deep Dive
Autophagy and Mitophagy in Neurodegeneration: A Deep Dive
The Scientist Creative Services Team and PerkinElmer
Robin Ketteler and Hélène Plun-Favreau discuss the importance of autophagy and mitophagy regulation in neurodegenerative diseases.
Neurons and muscle tissue
A Novel Player at the Neuromuscular Junction
Catherine Offord | Sep 12, 2022
The muscle transmembrane protein Vangl2 helps organize the development and maintenance of connections between muscles and motor neurons, a study concludes.
Illustration of RNAs
Infographic: Noncoding RNA in the Brain
Christie Wilcox | Sep 12, 2022
Neurologically important noncoding RNAs come in many shapes and sizes.
A Rising Star Launches Brain Power into Outer Space
Science Philosophy in a Flash - A Rising Star Launches Brain Power into Outer Space
Iris Kulbatski, PhD
Alysson Muotri shares how tapping into his inner creative spark fuels his pursuit of science.
Illustration of a human and Neanderthal skull side by side.
Mutation Linked to Difference Between Human and Neanderthal Brains
Dan Robitzski | Sep 9, 2022
A single amino acid substitution in a protein causes increased neuron production in the frontal lobes of humans compared to Neanderthals—a tiny difference that could have given our species a cognitive edge, researchers say.
Adipose tissue under the microscope appearing as red blobs on a white background
Mouse Brains Appear to Eavesdrop on Their Fat
Alejandra Manjarrez | Sep 9, 2022
For the first time, a team visualizes sensory nerves projecting into adipose tissue in mice and finds these neuronal cells may counteract the local effects of the sympathetic nervous system.
Raising the Bar for Biomarkers and Early Diagnostics in Neurodegenerative Disease
Raising the Bar for Biomarkers and Early Diagnostics in Neurodegenerative Disease
Fortis Life Sciences
Identifying novel biomarkers of Parkinson’s disease enables early diagnosis and treatment monitoring.
blue-gloved hands injecting mouse with syringe
Sex of Researcher Influences Ketamine’s Effects in Mice: Study
Shawna Williams | Sep 8, 2022
The findings likely have implications for animal research far beyond the study of antidepressants.
A 3D rendering of a neuron
Independent FDA Advisory Panel Recommends Approving ALS Drug
Amanda Heidt | Sep 8, 2022
The group’s 7-2 ruling in favor of the therapeutic represents a shift from previous deliberations, in which data on its effectiveness was deemed insufficient.
The Mosaic Brain
Sejal Davla, PhD
How somatic mutations cause brain diseases
LAKSAMEE CAVE
Clinton Cave Investigates How Brain Cells Communicate
Andy Carstens | Sep 1, 2022
The Middlebury College neuroscientist explores enzymes that affect brain cell development and neurodegeneration.
Brightly colored intersecting lines, creating a chaotic pattern that resembles a subway map.
Monkeys Look for Patterns that Aren’t There—Just Like Humans Do
Dan Robitzski | Aug 31, 2022
Macaques continued to search for answers to an unsolvable laboratory task, seemingly refusing to believe that the correct answers were random and inconsistent.