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Gut Organoid Transplants Produce Colorectal Cancer in Mice
Diana Kwon | Apr 30, 2017
By implanting patient- or rodent-derived mini-guts into mice, scientists can rapidly create more-accurate murine models of the disease
Developing Brains in Dishes
Ashley P. Taylor | Apr 26, 2017
Two studies report methods to mimic human fetal brain development using neurons derived from human induced pluripotent stem cells that form 3-D, brain-like structures.
Researchers Argue for “Embryoid” Ethics Revamp
Bob Grant | Mar 22, 2017
Scientists issue a call to reconsider the rules governing the creation of tissues, organs, and other structures made possible by recent advances in synthetic biology.
Will Organs-in-a-Dish Ever Replace Animal Models?
Tanya Lewis | Jul 19, 2016
Increasingly sophisticated tissue organoids can model many aspects of disease, but animal studies retain a fundamental role in research, scientists say.
With CRISPR, Modeling Disease in Mini Organs
Tanya Lewis | May 6, 2016
Organoids grown from genetically edited stem cells are giving scientists a new tool to screen drugs and test treatments.
Mini Brains Model Zika Infection
Tanya Lewis | Apr 22, 2016
Researchers create cerebral organoids in 3-D–printed bioreactors that can be used to model Zika infection.
Zika Seeks, Destroys Developing Neurons
Tanya Lewis | Apr 11, 2016
The virus infects and kills human neural stem cells and impedes brain tissue development, according to a study.
Guts and Glory
Anna Azvolinsky | Apr 1, 2016
An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.
How Zika Infiltrates Developing Brains
Tanya Lewis | Mar 30, 2016
Zika virus may commandeer a receptor on the surface of neural progenitor cells, scientists show.
More Mini Brains
Jef Akst | Feb 17, 2016
Simple versions of brain organoids could serve as new models for testing the effects of drugs, researchers reported at this year’s AAAS meeting.