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Developing Brains in Dishes
Ashley P. Taylor | Apr 26, 2017
Two studies report methods to mimic human fetal brain development using neurons derived from human induced pluripotent stem cells that form 3-D, brain-like structures.
Researchers Argue for “Embryoid” Ethics Revamp
Bob Grant | Mar 22, 2017
Scientists issue a call to reconsider the rules governing the creation of tissues, organs, and other structures made possible by recent advances in synthetic biology.
Will Organs-in-a-Dish Ever Replace Animal Models?
Tanya Lewis | Jul 19, 2016
Increasingly sophisticated tissue organoids can model many aspects of disease, but animal studies retain a fundamental role in research, scientists say.
With CRISPR, Modeling Disease in Mini Organs
Tanya Lewis | May 6, 2016
Organoids grown from genetically edited stem cells are giving scientists a new tool to screen drugs and test treatments.
Mini Brains Model Zika Infection
Tanya Lewis | Apr 22, 2016
Researchers create cerebral organoids in 3-D–printed bioreactors that can be used to model Zika infection.
Zika Seeks, Destroys Developing Neurons
Tanya Lewis | Apr 11, 2016
The virus infects and kills human neural stem cells and impedes brain tissue development, according to a study.
Guts and Glory
Anna Azvolinsky | Apr 1, 2016
An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.
How Zika Infiltrates Developing Brains
Tanya Lewis | Mar 30, 2016
Zika virus may commandeer a receptor on the surface of neural progenitor cells, scientists show.
More Mini Brains
Jef Akst | Feb 17, 2016
Simple versions of brain organoids could serve as new models for testing the effects of drugs, researchers reported at this year’s AAAS meeting.
Probing Down Syndrome with Mini Brains
Bob Grant | Oct 20, 2015
Researchers create cerebral organoids using induced pluripotent stem cells from patient skin cells and characterize protein-expression changes linked to cognitive impairment.