An orange-brown pineapple sea cucumber, covered in wart-like growths, rests on the seafloor in front of some coral.
How the Sea Cucumber Defends Itself . . . From Itself
The marine animals have evolved a unique molecular pathway enabling them to use toxins to fight off invaders without poisoning themselves in the process.
How the Sea Cucumber Defends Itself . . . From Itself
How the Sea Cucumber Defends Itself . . . From Itself

The marine animals have evolved a unique molecular pathway enabling them to use toxins to fight off invaders without poisoning themselves in the process.

The marine animals have evolved a unique molecular pathway enabling them to use toxins to fight off invaders without poisoning themselves in the process.

ABOVE: © ISTOCK.COM, RAINERVONBRANDIS
para-aminosalicylic acid, ecology, immunology
A section of a mouse distal colon showing luminal contents with bacteria in magenta, the mucus lining (green) and the epithelial cell barrier of the gut (blue, right).
Mapping the Neighborhoods of the Gut Microbiome
Abby Olena | Jul 1, 2022
Researchers are going beyond fecal samples to understand how the patterns of commensal microbes in the gastrointestinal tract influence development and health.
Photo taken from the perspective of a lab worker in a white coat and purple gloves preparing multiple fecal transplant capsules at a time.
Banking Previous Poos: Could a Transplant of Feces from Your Past Heal You?
Dan Robitzski | Jun 30, 2022
The Scientist spoke with Brigham and Women’s Hospital and Harvard Medical School researchers Scott Weiss and Yang-Yu Liu, who propose that people bank stool samples when they’re young and healthy so that they can be transplanted to rejuvenate the gut microbiome later on.
spatial CRISPR screen for cancer
A Brave New World for Spatial Genomics in Cancer Research
Nele Haelterman, PhD | Jun 27, 2022
A new CRISPR screening technology allows scientists to recreate tumor heterogeneity in vivo and study how it affects all aspects of cancer biology.
Artist’s rendering of aquamarine T cells in front of a blue and green background.
Study Links Stress to a Faster-Aging Immune System
Margaret Osborne | Jun 21, 2022
Health data from 5,744 adults over the age of 50 reveals an association between stressors such as discrimination and a relatively small proportion of younger infection-fighting immune cells.
A small, brown mouse runs on a narrow, miniature treadmill
How Exercise Helps Mice Fight Pancreatic Cancer
Dan Robitzski | Jun 15, 2022
A study reveals a molecular pathway linking exercise to an amped-up immune response to pancreatic cancer and greater responsiveness to treatment.
Reinvigorating the Immune System to Attack Cancer Cells Using Highly Specific Antibodies
Reinvigorating the Immune System to Attack Cancer Cells Using Highly Specific Antibodies
Fortis Life Sciences | Jun 20, 2022
Cancer immunotherapy targets the tumor microenvironment, blocking the molecular pathways that tumors exploit to prevent immune cell activity.
teabag with green tag on a white background
Spilling the Tea: Insect DNA Shows Up in World’s Top Beverage
Shawna Williams | Jun 14, 2022
The Scientist speaks with Trier University’s Henrik Krehenwinkel, whose group recently detected traces of hundreds of arthropod species from a sample of dried plants—in this case, the contents of a tea bag.
Vaccine illustration 
Infographic: Inducing Active Immunity Against Opioid Overdose
Tori Rodriguez | Jun 13, 2022
How scientists aim to induce an immune response against addictive drugs
iStock
The Scientist Speaks - To Conserve and Protect: The Quest for Universal Vaccines
Niki Spahich, PhD | May 24, 2022
Patrick Wilson discusses the challenges in designing universal vaccines and his work developing one for influenza.
Illustration of a syringe with a person falling out of a bottle of pills
Opioid Vaccines as a Tool to Stem Overdose Deaths
Tori Rodriguez | Jun 13, 2022
Researchers are turning to the immune system for help in treating addiction and preventing overdose.
Spraying spray bottle
Nasal Vaccines Are Commercially High Risk, Perhaps High Reward
Jef Akst | Jun 13, 2022
Dozens of intranasally delivered vaccines targeting SARS-CoV-2 are in development. Could they pave the way for widespread nasal vaccination in the future?
Using Single Cell Proteomics to Understand Human Health and Disease
Using Single Cell Proteomics to Understand Human Health and Disease
The Scientist Creative Services Team, 10x Genomics | May 5, 2022
Miriam Merad and Harrison Specht will discuss how single cell proteomics complement other omics methods to provide insight into disease pathophysiology and treatment.
animation showing how proximity affects viral transmission
Monkeypox Likely Spread Undetected in US Before Recent Reports  
Andy Carstens | Jun 6, 2022
Two strains of monkeypox have been detected in the US, suggesting the virus has been circulating in the country for some time, the CDC says.
Ribbon weed meadow in Shark Bay, Western Australia
World’s Largest Organism Discovered Underwater
Andy Carstens | Jun 2, 2022
Off the western Australian coast, in Shark Bay, a field of seagrass big enough to cover Washington, DC, has flourished for more than four millennia, a new study finds.
Cell-Free DNA as Disease Biomarkers
Cell-Free DNA as Disease Biomarkers
The Scientist Creative Services Team | Apr 22, 2022
In this webinar, Stella Goulopoulou and Iwijn de Vlaminck will discuss how they analyze cell-free DNA to identify biomarkers of various diseases and their complications, including preeclampsia, COVID-19, and transplant rejections.
Illustration showing rod-shaped Mycobacterium tuberculosis bacteria in the lungs of a person with tuberculosis
Delayed T cell Response Allows Tuberculosis to Gain Foothold in Monkeys
Anna Napolitano | Jun 1, 2022
The results could help guide the design of new vaccines for the disease.
Microscopic image of nerves in the eye, a pathogen, and t cells
Science Snapshot: Eye Immunity
Lisa Winter | May 26, 2022
Researchers find that tissue-resident memory T cells in the corneas of mice engender a lasting immune response.
An Improved Way to Detect CAR T Cells and SARS-CoV-2-Binding Cells
Technique Talk: An Improved Way to Detect CAR T Cells and SARS-CoV-2-Binding Cells
The Scientist Creative Services Team, Bio-Techne | Apr 13, 2022
Jody Bonnevier will discuss the advantages of Fluorokines™ for detecting and investigating CAR T cells and other key drivers of the immune system.
Outlines of people in multiple colors
HHMI to Award More than $1 Billion to Promote Equity in Research
Andy Carstens | May 26, 2022
A new program will provide 150 early-career scientists committed to advancing diversity, inclusion, and equity up to $8.6 million each.