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Illustration of myelinated neuron axons in light blue, with spindly blue and purple cells interspersed among them.
A Gene Variant Linked to Alzheimer’s May Disrupt Myelin Production
The APOE4 variant causes cholesterol buildup in the cells that make protective fatty sheaths for neurons, possibly helping explain its role in neurodegeneration.
A Gene Variant Linked to Alzheimer’s May Disrupt Myelin Production
A Gene Variant Linked to Alzheimer’s May Disrupt Myelin Production

The APOE4 variant causes cholesterol buildup in the cells that make protective fatty sheaths for neurons, possibly helping explain its role in neurodegeneration.

The APOE4 variant causes cholesterol buildup in the cells that make protective fatty sheaths for neurons, possibly helping explain its role in neurodegeneration.

protozoans, disease & medicine, neuroscience, cell & molecular biology
illustration of cancer cells moving
Cancer Cells Gather Speed in Thicker Fluids
Holly Barker | Nov 22, 2022 | 4 min read
Viscous solutions accelerate the migration of tumor cells and may enable metastasis, according to a new study.
A tetraplegic patient navigates a thought-controlled wheelchair
Tetraplegic Patients Take Mind-Controlled Wheelchair for a Spin
Christie Wilcox | Nov 18, 2022 | 2 min read
The mobility device interprets its paralyzed user’s thoughts to steer through cluttered spaces, a study reports.
Science Philosophy in a Flash - Paul George 
Science Philosophy in a Flash - Wired to Regenerate
Iris Kulbatski, PhD | 1 min read
Paul George shares how a dual career as a physician and scientist enriches his research.
Turkey, mashed potatoes, stuffing, pumpkin pie and sides on a table
The Smell of Food Affects Metabolism in Fasting Mice
Shafaq Zia | Nov 18, 2022 | 3 min read
The odor prompted the animals’ fat cells to release lipids into circulation.
Rendering of a light blue NLRP3 inflammasome against a black background
Inflammation in Brain’s Immune Cells Triggers Depressive Behavior in Mice
Dan Robitzski | Nov 17, 2022 | 5 min read
In stressful conditions, specialized protein complexes in microglia induce neurotoxic activity in astrocytes that leads to the change in behavior.
Learn about effective biomarker detection from the blood
Next-Level Neuroscience
The Scientist Creative Services Team and MilliporeSigma | 1 min read
Researchers use Single Molecule Counting (SMC®) technology to probe brain biomarkers.
Cells with miRNA activity reporter glowing
MicroRNAs Can Boost Gene Expression: Study
Holly Barker | Nov 15, 2022 | 3 min read
The tiny strings of RNA promote translation of a protein implicated in cancer, a hint they could regulate gene expression in more ways than previously thought.
(Left) The optic lobes are thought to be involved in visual processing. In this study, researchers found that guppies with larger optic lobes more quickly learned a visual discrimination task—identifying which color well contained food. (Right) The fish telencephalon is thought to be involved in spatial learning, memory, and inhibitory control. Here, the researchers found that a larger telencephalon might enhance the fish’s cognitive flexibility, allowing them to more quickly associate food with a new color after the researchers switched it.
Infographic: Two Guppy Brain Regions May Help Them Learn Tasks
Natalia Mesa | Nov 14, 2022 | 1 min read
While guppies with larger optic lobes were champions at learning visual discrimination tasks, guppies with larger telencephalons fared better when researchers switched things up.
Capturing Brain Complexity in Assembloids 
Capturing Brain Complexity in Assembloids
The Scientist Creative Services Team | 1 min read
In this webinar, Jimena Andersen and Jens Schwamborn will describe the next-generation brain organoids that combine multiple brain regions and cell types in 3D cultures.
Photo of a Guppy fish
Fish Brain Region Size Correlates with Cognitive Flexibility
Natalia Mesa | Nov 14, 2022 | 3 min read
The relative sizes of specific parts of the guppy brain may explain why some fish are better at learning certain tasks than others. 
A visualization of a spinal cord with neurons highlighted in red
Scientists Identify Neurons Needed to Walk After Paralysis
Amanda Heidt | Nov 10, 2022 | 3 min read
Nine people with spinal injuries walked again after electrical stimulation, allowing researchers to pinpoint neurons likely underlying their recovery.
Neurons traversing the brain with an area of red neurodegeneration
LabTalk Podcast - The New Era of Neurodegeneration Research
The Scientist Creative Services Team | 1 min read
Erdem Gültekin Tamgüney discusses the future of neurodegeneration research and his work exploring the link between stroke and Parkinson’s disease.
Portrait of Chuck Stevens
Famed Neuroscientist Charles Stevens Dies at 88
Lisa Winter | Nov 9, 2022 | 3 min read
His work blended biology and the methods of theoretical physics to explain neural networks. 
fluorescently labeled microscopy cross-section of bone
Cancer Cells in Mice May Hitch a Ride with Bone-Healing Stem Cells
Andy Carstens | Nov 7, 2022 | 4 min read
Researchers have long observed a connection between bone metastasis and remodeling, which might be due to a close connection between the two cell types. 
Time Traveling Mini-Brains on a Mission to Conquer Space
Time Traveling Mini-Brains on a Mission to Conquer Space
Iris Kulbatski, PhD | 4 min read
Alysson R. Muotri discusses his launch of brain organoids into outer space and how microgravity enriches our understanding of brain development and disease.
magic mushrooms on a while background
Psilocybin Relieves Some Treatment-Resistant Depression Cases: Trial
Shawna Williams | Nov 3, 2022 | 2 min read
The research has caveats, including side effects and a lack of durability in the benefits of a single dose.
Circular clusters of <em>Staphylococcus aureus</em> drift on a blue background.
Retching Mice Reveal the Brain Circuit Behind Vomiting
Katherine Irving | Nov 2, 2022 | 2 min read
The discovery could one day lead to the development of better antinausea medications.
Motor neurons, undergoing degeneration in ALS
Mutant T Cells That Drive Amyotrophic Lateral Sclerosis (ALS) Progression May React To a Brain Antigen
Nele Haelterman, PhD | 4 min read
Scientists discovered a possibly autoreactive T cell population that forecasts and supports disease progression.
Illustration of green fluorescent bacterial cells.
Cocaine Use Creates Feedback Loop with Gut Bacteria: Mouse Study
Alejandra Manjarrez | Nov 1, 2022 | 3 min read
A jolt of norepinephrine in the mouse gut facilitates colonization by certain microbes, which in turn deplete glycine, enhancing cocaine-induced behaviors.
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