Alzheimer’s-Linked Mutation Causes Blockages in Neurons
Alzheimer’s-Linked Mutation Causes Blockages in Neurons
The variant causes a buildup of BACE1 protein in axons in cultured neurons and mice. Researchers say it might be time to rethink failed trials that inhibit BACE1 to treat the neurodegenerative disease.
Alzheimer’s-Linked Mutation Causes Blockages in Neurons
Alzheimer’s-Linked Mutation Causes Blockages in Neurons

The variant causes a buildup of BACE1 protein in axons in cultured neurons and mice. Researchers say it might be time to rethink failed trials that inhibit BACE1 to treat the neurodegenerative disease.

The variant causes a buildup of BACE1 protein in axons in cultured neurons and mice. Researchers say it might be time to rethink failed trials that inhibit BACE1 to treat the neurodegenerative disease.

single-nucleotide polymorphism, neuroscience
Black in X Addresses Long-Standing Inequity in STEM
Black in X Addresses Long-Standing Inequity in STEM
Lisa Winter | Nov 16, 2020
In a year of racial tumult, Black scientists are uniting for visibility and action. 
Zebra Finches Recognize the Calls of Over 40 Fellow Finches
Zebra Finches Recognize the Calls of Over 40 Fellow Finches
Amanda Heidt | Nov 13, 2020
Their ability to distinguish between individuals is strong evidence for fast mapping, a learning tool generally thought to belong only to humans.
Single-cell Secrets
Single-cell Secrets
The Scientist Creative Services Team | Oct 30, 2020
Single-cell research reveals new insights into SARS-CoV-2, the opioid crisis, neurogenesis, and fertility.
New Tracer Gives Clear Picture of Alzheimer’s and Other Dementias
New Tracer Gives Clear Picture of Alzheimer’s and Other Dementias
Ian Le Guillou | Oct 29, 2020
An imaging agent reveals aggregated tau protein in the brain during PET scans and could improve the diagnosis of neurodegenerative diseases, particularly tauopathies.
This Ogre-Faced Spider Can Hear Prey Through Its Legs
This Ogre-Faced Spider Can Hear Prey Through Its Legs
Katarina Zimmer | Oct 29, 2020
The tropical net-casting spider Deinopis spinosa joins several other arachnid species that can hear sounds from afar without the help of a web, or even ears—an ability that aids its unique hunting tactics.
Book Excerpt from <em>The Nature of Fear</em>
Book Excerpt from The Nature of Fear
Daniel T. Blumstein | Oct 21, 2020
In the book’s prologue, author Daniel T. Blumstein explains his introduction to the study of fear.
Breaking Down Barriers
Breaking Down Barriers
The Scientist Creative Services Team | Oct 19, 2020
Looking at the future of neurodegeneration research!
Serotonin and Dopamine Linked to Decision-Making: Study
Serotonin and Dopamine Linked to Decision-Making: Study
Amanda Heidt | Oct 16, 2020
In a first-of-its-kind study, researchers monitored subsecond changes in levels of the neurotransmitters in the human brain, unlocking new insight into their function.
Study Points to Novel Role for Microglia in Down Syndrome
Study Points to Novel Role for Microglia in Down Syndrome
Catherine Offord | Oct 6, 2020
Overactive immune cells identified in a mouse model and in postmortem human brain tissue may offer a potential therapeutic target for cognitive delays associated with the condition, researchers report.