An engineered coronavirus with the N501Y mutation—one of many mutations present in the emerging B.1.1.7 and 501.V2 variants of the coronavirus—is neutralized by the sera of COVID-19 vaccine recipients.

An additional mutation in the spike protein of the coronavirus may help it elude antibody recognition, and scientists are investigating if current vaccines will protect against it.

The head of Operation Warp Speed says that by spreading out doses of the Moderna vaccine, more people would be able to get some level of protection sooner, a strategy opposed by other experts.

Last year humanity confronted our biggest challenge in a century. Science helped us see the light at the end of the tunnel. But we need to keep moving forward to emerge.

Take a break from the bench to puzzle and peruse.

The world was rocked by the COVID-19 pandemic this year, but researchers rose to all manner of challenges.

The pandemic spurred innovation in a variety of ways, from CRISPR-based diagnostics to cell biology benchwork at home.

Alessandro Sette and Shane Crotty discuss the T cell response to SARS-CoV-2 and the implications for vaccine design and robust immune memory.

Take a break from the bench to puzzle and peruse.