ISTOCK, GEORGEJASON
Microglia Cause Cognitive Decline in Obese Mice
Microglia Cause Cognitive Decline in Obese Mice
The brain’s immune cells gobble up synapses in the hippocampi of rodents fed high-fat or high-sugar diets.
Microglia Cause Cognitive Decline in Obese Mice
Microglia Cause Cognitive Decline in Obese Mice

The brain’s immune cells gobble up synapses in the hippocampi of rodents fed high-fat or high-sugar diets.

The brain’s immune cells gobble up synapses in the hippocampi of rodents fed high-fat or high-sugar diets.

Week in Review, genetics & genomics, neuroscience
Anti-CRISPR Proteins Found that Block Cas12a Nuclease
Anti-CRISPR Proteins Found that Block Cas12a Nuclease
Ashley Yeager | Sep 6, 2018
Using bioinformatics, two teams of scientists identified inhibitory proteins for Cas9’s relative.
Exercise’s Benefits to Dementia Can Be Made Chemically
Exercise’s Benefits to Dementia Can Be Made Chemically
Ruth Williams | Sep 6, 2018
Boosting both neurogenesis and a brain-derived growth factor can mimic the cognitive benefits of exercise in a mouse mode of Alzheimer’s disease.
RNA Detection Tool Debate Flares Up at ACS Meeting  
RNA Detection Tool Debate Flares Up at ACS Meeting  
Katarina Zimmer | Sep 5, 2018
Researchers have flagged several issues with so-called SmartFlares over the years, and it’s still unclear why they don’t appear to work under certain circumstances.
Early Results of First In Vivo Gene-Editing Trial Encouraging
Early Results of First In Vivo Gene-Editing Trial Encouraging
Kerry Grens | Sep 5, 2018
Two patients who received Sangamo’s zinc finger–based treatment for Hunter syndrome have lower biomarkers of the condition, but no signs of new enzyme production.
Image of the Day: Ocean Wonder
Image of the Day: Ocean Wonder
Sukanya Charuchandra | Sep 4, 2018
Molecules similar to those produced by sea anemones are neuroprotective in a mouse cell model of Alzheimer’s disease.
US Companies Launch CRISPR Clinical Trial
US Companies Launch CRISPR Clinical Trial
Catherine Offord | Sep 3, 2018
The Germany-based study will test an ex vivo genome-editing therapy for the inherited blood disorder β-thalassemia.
CRISPR Treatment for Duchenne Muscular Dystrophy Helps Dogs
CRISPR Treatment for Duchenne Muscular Dystrophy Helps Dogs
Catherine Offord | Aug 31, 2018
Researchers boosted levels of the dystrophin protein to nearly normal levels in a canine model of the disease.
Limited Meal Times Prevent Obesity in Mice Prone to Gaining Weight
Limited Meal Times Prevent Obesity in Mice Prone to Gaining Weight
Abby Olena | Aug 30, 2018
Even in mice with a busted circadian clock and an unhealthy diet, carefully timed feeding overcomes the rodents’ predispositions for metabolic diseases.
Tiny Tunnels Run from the Skull to the Brain: Study
Tiny Tunnels Run from the Skull to the Brain: Study
Ashley Yeager | Aug 29, 2018
Immune cells travel through these passageways to get to injured tissue quickly, researchers say.