Cell-Signaling A Cascade of Kinases, Phosphatases, and Cytokines

Date: July 5, 1999Table of Cell Signaling Tools At today's research pace, new signaling mechanisms within and between cells are emerging not one by one but in a chain reaction. Each new discovery has strong implications for previously established models, sometimes overturning several assumptions at once. With such a large number of interacting systems--from cell adhesion to differentiation and apoptosis--and receptor pathways, keeping up with the wealth of cell-signaling research tools can be l

Deborah Noble
Jul 4, 1999

Date: July 5, 1999Table of Cell Signaling Tools

At today's research pace, new signaling mechanisms within and between cells are emerging not one by one but in a chain reaction. Each new discovery has strong implications for previously established models, sometimes overturning several assumptions at once. With such a large number of interacting systems--from cell adhesion to differentiation and apoptosis--and receptor pathways, keeping up with the wealth of cell-signaling research tools can be like hunting for nails in a hardware superstore. The problem isn't that the store doesn't have them, it's that there are so many different kinds to choose from, it's hard to know where to look first.


Cell-signaling diagram supplied by Oncogene Research
Cell signaling starts when a hormone, neurotransmitter, cytokine, drug, or other external signaling molecule reaches the cell membrane from outside and binds to a receptor protein on the cell surface. The ligand activates the...

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