Graphic: Leza Berardone |
![]() |
The two-hybrid system is an in vivo assay, so proteins are more likely to be in their native conformation, and weak and/or transient interactions that may evade detection in vitro can be detected. Conventional two-hybrid systems are based on the fact that many eukaryotic transcriptional activators contain two physically and functionally separate domains, both of which are required for...
Interested in reading more?
Become a Member of
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?