Integral Connections

Click to view the PDF file: Suppliers of Integrin-Related Reagents Courtesy of Rick HorwitzReprinted with permission from the Journal of Cell BiologyPaxillin-GFP in WI38 human fibroblast cells showing paxillin turnover as cells migrate. The image is an overlay of 2 separate time points. Editor's note: A group of scientists led by M. Amin Arnaout at Massachusetts General Hospital published the first crystal structure of the human integrin aVb3 extracellular domain, on September 9, 2001.(www.sc

Deborah Fitzgerald
Aug 19, 2001
Click to view the PDF file:

Suppliers of Integrin-Related Reagents

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Courtesy of Rick Horwitz
Reprinted with permission from the Journal of Cell Biology

Paxillin-GFP in WI38 human fibroblast cells showing paxillin turnover as cells migrate. The image is an overlay of 2 separate time points.



Editor's note: A group of scientists led by M. Amin Arnaout at Massachusetts General Hospital published the first crystal structure of the human integrin aVb3 extracellular domain, on September 9, 2001.(www.scienceexpress.org: 10.1126/science.1064535)

Adherent cells secrete, mold, reside in, and interact with a dynamic, proteinaceous milieu known as the extracellular matrix. Although it occupies the intercellular space and binds cells and tissues together when appropriate, this matrix is much more than just a sticky goo. Rather, it is an information-rich medium that is involved in a number of critical biological processes, such as morphogenesis and differentiation. Cells interact with the extracellular...

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