Refining Transgenic Mice

Volume 16 | Issue 13 | 34 | Jun. 24, 2002 Previous | Next Refining Transgenic Mice Emerging technologies allow researchers to make tissue- and developmental stage-specific knockouts | By Leslie Pray Image: Courtesy of Taconic Farms MOUSE HOUSE: Scientists at Taconic's Molecular Analysis Laboratory genotype transgenic rat and mouse lines. Mice have been freeloading on humans for millenni

Leslie Pray
Jun 23, 2002
lab consumer
Volume 16 | Issue 13 | 34 | Jun. 24, 2002

Refining Transgenic Mice

Emerging technologies allow researchers to make tissue- and developmental stage-specific knockouts | By Leslie Pray



Image: Courtesy of Taconic Farms
 MOUSE HOUSE: Scientists at Taconic's Molecular Analysis Laboratory genotype transgenic rat and mouse lines.

Mice have been freeloading on humans for millennia. Now, in laboratories around the world, scientists are returning the favor. Model systems such as the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans are actually easier to work with than mice, but mice are more closely related to humans, making them better models of human physiology. "For modeling genetic diseases like breast cancer, you definitely need mammals," says Kay-Uwe Wagner, a molecular biologist at the Eppley Institute for Research in Cancer and Allied Diseases, Omaha, Neb.

Early in the 20th century, geneticists used inbred mouse strains for much...

Interested in reading more?

Become a Member of

Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member?