Tissue Microarrays Coming of Age

Courtesy of Marisa Dolled-Filhart, Robert L. Camp, and David L. Rimm  CORE TECHNOLOGY: Images of a breast cancer tissue microarray core immunofluorescently stained with (clockwise from top left) a rabbit pan-cytokeratin antibody, an Estrogen Receptor antibody, and DAPI, allowing for differential fluorescent tagging of each. If there's anyone who can appreciate tissue microarrays, it's histology technician Sabina Magedson. Having worked in a pathology laboratory at M.D. Anderson Cancer Ce

Laura Lane
Sep 7, 2003
Courtesy of Marisa Dolled-Filhart, Robert L. Camp, and David L. Rimm
 CORE TECHNOLOGY: Images of a breast cancer tissue microarray core immunofluorescently stained with (clockwise from top left) a rabbit pan-cytokeratin antibody, an Estrogen Receptor antibody, and DAPI, allowing for differential fluorescent tagging of each.

If there's anyone who can appreciate tissue microarrays, it's histology technician Sabina Magedson. Having worked in a pathology laboratory at M.D. Anderson Cancer Center in Houston for years, Magedson knows all too well the tedium of staining and analyzing hundreds upon hundreds of individual tissue sections--all in the name of one part, of one experiment.

Increasingly, such low-throughput monotony is giving way to 'omics-style science, thanks to tissue microarrays (TMAs). Originally developed in the mid-1980s, tissue arrays never really caught on until Juha Kononen, who was then a postdoctoral fellow at the National Human Genome Research Institute, developed a relatively simple way to construct them...

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