DNA, RNA Probes Help Investigators Narrow The Search For Genes

For Genes Author: Holly Ahern For a geneticist, pinpointing a mutation in a human gene that might be responsible for an inherited disease can be likened to the proverbial search for a needle in a haystack. While mo-lecular biologists sift through the 3 billion base pairs in the human genome in search of disease-causing genes, other scientists choose to approach the problem from the perspective of the mouse, a model system for mammal research. Because mice and humans are members of the same gr

Holly Ahern
Nov 26, 1995

For Genes Author: Holly Ahern

For a geneticist, pinpointing a mutation in a human gene that might be responsible for an inherited disease can be likened to the proverbial search for a needle in a haystack. While mo-lecular biologists sift through the 3 billion base pairs in the human genome in search of disease-causing genes, other scientists choose to approach the problem from the perspective of the mouse, a model system for mammal research.

Because mice and humans are members of the same group of animals and develop similar diseases, mapping mouse mutations that appear to be linked to a genetic disease is considered by many scientists a springboard from which disease-causing genes in humans might also be mapped.

Amplicor AMPLICOR LINE: Roche's kits have probes that bind to specific target sequences in pathogenic organisms. Whether experiments are performed with the human genome or with the mouse genome, locating a...

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