Becton Dickinson's Falcon® HTS FluoroBlock Inserts
FluoroBlok is a proprietary colored PET membrane insert that fits into an individual well of a 24-well microplate. The membrane is available in three pore sizes (1, 3, and 8 µm). Besides cell migration and chemotaxis, applications include tumor cell/bacterial invasion, cell-cell adhesion, signaling, and leakage to assess tightness of cell junctions. Cell monolayer (e.g., Caco-2 cell) permeability can be assayed as a model system for an oral bioavailability assay. Since there is a linear relationship between fluorescence and cell number, the number of migrating cells can be quantified. Cell-based high throughput...
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