Mutation Station: Transgenomic's WAVE System Eliminates Base-by-Base Search

A minor alteration in a single gene of the human body can be a major contributor to the development of a wide spectrum of diseases ranging from cystic fibrosis to cancer. With the Human Genome Project in full swing, the number of genes available to analyze for these changes is growing daily. The increased demand for genetic testing also requires rapid screening capabilities. Transgenomic Inc. recognized this need and has designed an automated high-throughput system for mutation detection. Trans

Amy Francis
Sep 26, 1999

A minor alteration in a single gene of the human body can be a major contributor to the development of a wide spectrum of diseases ranging from cystic fibrosis to cancer. With the Human Genome Project in full swing, the number of genes available to analyze for these changes is growing daily. The increased demand for genetic testing also requires rapid screening capabilities. Transgenomic Inc. recognized this need and has designed an automated high-throughput system for mutation detection. Transgenomic's WAVE Nucleic Acid Fragment Analysis System eliminates the need to search base by base for a single alteration by detecting mutations in regions of DNA as large as 1.5 kilobases at one time.


Transgenomic's temperature modulated heteroduplex analysis system
The WAVE System couples the efficiency of heteroduplex analysis (HA) with the convenience of chromatography in a highly automated system that makes mutation detection faster than blind sequencing or gel-based HA methods....