Picking a Needle out of a Haystack

Gel Microdrop System from One Cell Systems can ferret out rare protein secreting cells Imagine, if you will, a single cell suspended in a drop. Now picture that same cell secreting a protein, say an immunoglobulin. Now envision that secreting cell embedded in a matrix that binds the protein as it leaves the cell, and you have the idea of the microdrop hybridoma selection system available from One Cell Systems. A modification of the microdrop technology described in 1991 by James Weaver, Associ

Laura Defrancesco
Dec 6, 1998

Gel Microdrop System from One Cell Systems can ferret out rare protein secreting cells

Imagine, if you will, a single cell suspended in a drop. Now picture that same cell secreting a protein, say an immunoglobulin. Now envision that secreting cell embedded in a matrix that binds the protein as it leaves the cell, and you have the idea of the microdrop hybridoma selection system available from One Cell Systems. A modification of the microdrop technology described in 1991 by James Weaver, Associate Director of the Biomedical Engineering Center, Harvard/MIT, this technique can save weeks of time and tedium in the isolation and stabilization of protein-secreting cells. While microdrops are not a totally new idea, the development of a technology for making small, uniform droplets from a porous material--uniformity is one of the keys to the success of the microdrop assay--combined with a "capture web" of affinity-tagged agarose, it has...

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