Single nucleotide polymorphisms (SNPs) are the most common type of sequence variation in the human genome. These single-base variations at key sites in DNA are believed to be associated with susceptibility to certain diseases and differential response to pharmaceutical therapies. The detection and analysis of SNPs have typically relied on Sanger sequencing and electrophoresis for genomewide studies or hybridization-based methods whose accuracy may be inadequate.
Pyrosequencing reads SNPs by chemiluminescence
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