Edited by: Ricki Lewis
D. Broccoli, J.W. Young, T. de Lange, "Telomerase activity in normal and malignant hematopoietic cells," Proceedings of the National Academy of Sciences, 92:9082-6, 1995. (Cited in 95 publications through June 1997)

Comments by Titia de Lange, Rockefeller University


UNEXPECTED FINDING: Titia de Lange's lab at Rockefeller University used a sensitive assay to detect telomerase activity in noncancerous cells.
A paper that reports an unexpected finding is destined to be highly cited, and so it is for this 1995 article from the cell biology and genetics laboratory at the Rockefeller University, headed by Titia de Lange. She and colleagues Dominique Broccoli and Jim Young detected telomerase activity in normal, noncancerous cells.

The telomeres, or chromosome tips, of human somatic cells shrink with each cell division. In germline cells such as sperm and in malignant cells, chromosome length is maintained by telomerase, an enzyme that...

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