Extra Centrosomes Can Drive Tumor Formation in Mice

Mice engineered to overproduce the organelles involved in cell division spontaneously develop malignancies.

Diana Kwon
Diana Kwon
Apr 1, 2017

OVERCROWDED: A cell with too many centrosomes (each with two centrioles; green), extra mitotic spindles (red), and abnormally segregated DNA (blue)BRAMWELL LAMBRUS, HOLLAND LAB


The paper
M.S. Levine et al., “Centrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals,” Dev Cell, 40:313-22, 2017.

Three’s a crowd
More than a century ago, the German biologist Theodor Boveri observed that cancer cells often had extra centrosomes, organelles essential for the segregation of chromosomes during mitosis. This raised a question that scientists have since puzzled over for decades:
Is centrosome amplification a cause or effect of cancer?

See "A Cellar's Cellular Treasure"

Chicken or egg
In 2008, researchers found the first compelling evidence that extra centrosomes could drive tumor formation in flies. However, subsequent studies in mice failed to replicate the results, leading some to question the universality of extra centrosomes’ effects.

Master regulator...