EDITOR'S CHOICE IN MECHANOTRANSDUCTION
GRYGORCZYK R, FURUYA K, SOKABE M. J PHYSIOL. 2013 MAR 1;591(Pt 5):1195-215
R. Grygorczyk et al., “Imaging and characterization of stretch-induced ATP release from alveolar A549 cells,” J Physiol, 591:1195-215, 2013.
Extracellular signaling with ATP is a primitive method of cell communication that, in the lungs, stimulates the secretion of mucus, fluids, and surfactants. Cell physiologist Ryszard Grygorczyk of the University of Montreal and collaborators showed that mechanically stretching lung cells by more than 10 percent instigates ATP secretion in sufficient amounts to induce a physiological response.
Grygorczyk and colleagues stretched A549 cells—a human lung cancer cell line—with a computer-controlled machine mounted on a microscope that...