Growth Hormone Guidance

Intact growth hormone signaling pathways are needed for methionine restriction to extend mouse lifespan.

Jenny Rood
Mar 1, 2015

OLD MICE: Ames dwarf mice (above, right) outlive wild-type mice (above, left), but their life span is unresponsive to changes in dietary methionine levels.CHUCK KIMMERLE AT UNIVERSITY OF NORTH DAKOTA


The Paper
H.M. Brown-Borg et al., “Growth hormone signaling is necessary for lifespan extension by dietary methionine,” Aging Cell, 13:1019-27, 2014.

The paradox
Genetic defects in growth-hormone (GH) signaling extend life span in mice, as do diets minimizing the intake of a single amino acid, methionine. Yet scientists had previously observed that the Ames dwarf mouse, deficient in GH, lives longer but has upregulated methionine metabolism. Holly Brown-Borg of the University of North Dakota and her colleagues thus decided to examine how GH genetics and dietary methionine might interact to impact life span.

The diet
Brown-Borg’s team compared four groups of mice on three different diets. Ames dwarf mice, GH-receptor knockout mice, transgenic...