COURTESY OF ULRICH MUELLER
EDITOR'S CHOICE IN NEUROSCIENCE
C. Gil-Sanz et al., “Cajal-Retzius cells instruct neuronal migration by coincidence signaling between secreted and contact-dependent
guidance cues,” Neuron, 79:461-77, 2013.
During development, a large signaling molecule named reelin coordinates the outward migration of neurons from the inner neocortex, with help from a cell-adhesion molecule, cadherin 2. “The problem is that cadherin 2 is expressed all over the cortex in all cell types,” says Ulrich Mueller, a neuroscientist at The Scripps Research Institute in La Jolla, Calif. “How could you use that to make a specific connection?” Now Mueller and his team have shown that two cell-adhesion and signaling proteins called nectins guide neurons to specific cortical destinations.