EDITOR'S CHOICE IN INFECTIOUS DISEASE
COURTESY OF BRIAN YORDY
B. Yordy et al., “A neuron-specific role for autophagy in antiviral defense against herpes simplex virus,” Cell Host & Microbe, 12:334-45, 2012.
Activation of the immune system by interferons is important in battling viral infections, but it can also result in cell death—a path that spells trouble for infected nonrenewable cell types, such as neurons. It’s been shown that neurons can instead rely on autophagy to gobble up viral particles and stop infections, but it was unclear whether this response was critical to protecting neurons and whether it was a general mechanism used by other cell types.
Akiko Iwasaki at Yale University School of Medicine and her colleagues conducted a comparison of two...