EDITOR'S CHOICE IN CELL BIOLOGY
B.M. Webster et al., “Surveillance of nuclear pore complex assembly by ESCRT-III/Vps4,” Cell, 159:388–401, 2014.
Building the nuclear pore complex—gatekeeper to the genome—is no small feat for a cell; hundreds of proteins assemble to traffic content between the nucleus and the cytoplasm. To Patrick Lusk, a cell biologist at Yale University, it seemed likely that the assembly process, albeit essential, might fail on occasion. So his group set out to find whether there are any quality-assurance mechanisms to keep the assembly in order.
Conducting genetic assays in yeast, Lusk’s group identified the ESCRT-III complex as responsible for monitoring nuclear pore assembly and clearing malformed complexes. ESCRTs are known to bend membranes and assist in...