SUSAN STROME, PNAS, 113:3591-96, 2016
EDITOR'S CHOICE IN CELL AND MOLECULAR BIOLOGY
A.K. Knutson et al., “Reevaluation of whether a soma–to–germ-line transformation extends lifespan in Caenorhabditis elegans,” PNAS, 113:3591-96, 2016.
Germline cells are considered immortal, because, unlike somatic cells, they can theoretically replicate indefinitely. In 2009, a study by Gary Ruvkun’s lab at Harvard Medical School reported that an insulin-deficient, long-lived Caenorhabditis elegans mutant, daf-2, misexpressed genes coding for germline factors called P-granules in its somatic cells—a result the team linked back to the mutants’ longevity (Nature, 459:1079-84).
The findings piqued the curiosity of C. elegans researcher and P-granule expert Susan Strome of the University of California, Santa Cruz. Interested in performing related research, she...