COURTESY OF A. SHEIKH AND D. GREIF, YALE UNIVERSITY
EDITOR'S CHOICE IN CELL & MOLECULAR BIOLOGY
A.Q. Sheikh et al., “Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension,” Sci Transl Med, 7:308ra159, 2015.
Blood vessels are surrounded by a layer of smooth muscle that helps regulate blood flow. In healthy lungs, this muscular sleeve ends midway along the length of arterioles, which branch into capillaries. In pulmonary hypertension (PH), however, the muscle extends distally toward the capillary bed and stiffens the vessel.
Previous research in mice from Yale University’s Daniel Greif and colleagues found that oxygen deprivation (hypoxia), which can cause PH in humans and animal models, leads smooth muscle cells (SMCs) in the proximal and middle arteriole to dedifferentiate,...
The clonal expansion “is really a fascinating discovery that they’ve made,” says University of Virginia School of Medicine’s Gary Owens. “It’s the coolest paper I’ve read in some time.”
Greif says the group’s finding is “particularly exciting” because it suggests that this pathological muscle arises from a small number of specific progenitors, which could potentially be targets for treatments.