EDITOR'S CHOICE IN IMMUNOLOGY
K.L. Clayton et al., “Soluble Tim-3 is shed from CD8+ T cells by the sheddase ADAM10, is increased in plasma during untreated HIV infection, and correlates with HIV disease progression,” J Virol, doi:10.1128/JVI.00006-15, 2015.
The Tim-3 protein on the surface of T cells is thought to dampen the immune response to prevent harmful overactivation. But in HIV infections, this protective mechanism is hijacked to exhaust T-cell function. Previous studies had found soluble Tim-3 (sTim-3) in the blood of cancer patients, but the role of circulating Tim-3 in HIV infections was not known.
Kiera Clayton and her colleagues in Mario Ostrowski’s lab at the University of Toronto, along with collaborators elsewhere, analyzed the blood of people...