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R. Zhou et al., “A molecular motor, KIF13A, controls anxiety by transporting the serotonin type 1a receptor,” Cell Reports, 3:509-19, 2013.
Dysfunctions in the neurotransmitter serotonin and its receptors have long been associated with anxiety. University of Tokyo cell biologist Nobutaka Hirokawa and colleagues have found that the kinesin motor KIF13A transports serotonin type 1a receptors to the cell membrane, and that defects in KIF13A result in anxiety-related behavior in mice.
Hirokawa previously found that KIF molecular motors are involved in diverse processes, including nerve development and higher brain functions such as learning and memory. The function of KIF13A, however, was a mystery. While performing behavioral...