EDITOR'S CHOICE IN CELL AND MOLECULAR BIOLOGY
S. Tohme et al., “Neutrophil extracellular traps promote the development and progression of liver metastases after surgical stress,” Cancer Res, doi:10.1158/0008-5472.CAN-15-1591, 2016.
The cure and the cause
For colorectal cancers that have metastasized to the liver, surgeons are often called in to remove tumors. But in the majority of cases, the cancer comes back. Allan Tsung, a cancer surgeon at the University of Pittsburgh School of Medicine, suspected that the procedure itself—specifically, the body’s own healing response to surgical stress—might contribute to recurrence.
Immune cells called neutrophils are first responders after injury caused by surgery. The cells are known to spew weblike DNA—a.k.a. neutrophil extracellular traps (NETs)—into the bloodstream. NETs...