The Literature
Productivity Paradox
Productivity Paradox
Jim Daley | Jun 1, 2018
During the last ice age, there wasn’t much plant matter to eat on northern steppes, but herbivorous woolly mammoths were abundant. How did they survive?
Incomplete Immunity
Incomplete Immunity
Jim Daley | Jun 1, 2018
By combining experimental data with computer models, researchers were able to predict a pathogen’s evolution toward more virulence.
Condensin Folds DNA Through Loop Extrusion
Condensin Folds DNA Through Loop Extrusion
Diana Kwon | Jun 1, 2018
By observing the activity of a protein complex in real time, researchers have uncovered new evidence for a long-standing theory.
Copper Connections
Copper Connections
Jim Daley | May 1, 2018
Researchers initially set out to investigate the relationship between copper homeostasis and the rare Menkes disease, but they also found links to Parkinson’s.
Big Data in 3 Dimensions
Big Data in 3 Dimensions
Jim Daley | May 1, 2018
Viewing oncogenic mutations in 3-D showed that they cluster together on folded proteins.
Certain Glial Cells Appear to Help Prevent Muscle Fatigue
Certain Glial Cells Appear to Help Prevent Muscle Fatigue
Ashley Yeager | May 1, 2018
The flow of calcium and potassium ions keeps muscles contracting in the diaphragms of neonatal mice, but if a key protein receptor is missing, fatigue sets in more quickly.
Mutant RAS Proteins Team Up for Oncogenicity
Mutant RAS Proteins Team Up for Oncogenicity
Jim Daley | Apr 1, 2018
Mice with cancer whose KRAS proteins couldn’t link together had much better survival outcomes than those whose oncogenic mutant paired with wild-type KRAS.
Boosting Immunotherapy Treatments in Mouse Colon Cancer
Boosting Immunotherapy Treatments in Mouse Colon Cancer
Jim Daley | Apr 1, 2018
Mice treated with an immunostimulant had better outcomes when researchers blocked the expression of TNFR2, a compound that helps tumors evade immune attack.
Chromosomal Instability Drives Cancer Metastasis
Chromosomal Instability Drives Cancer Metastasis
Jim Daley | Apr 1, 2018
In the presence of cytosolic DNA, cancer cells activate antiviral pathways that disguise them as immune cells.
Bacterial Cell Envelope Size is Key to Membrane Stress Response
Bacterial Cell Envelope Size is Key to Membrane Stress Response
Diana Kwon | Mar 1, 2018
Transmission of stress signals in E. coli is dependent on the distance between its inner and outer membranes.