Menu

Bio-Rad Launches CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin for Process Protein Purification

Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb), a global leader of life science research and clinical diagnostic products, today announced the launch of two new chromatography media for process protein purification: CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin.

Sep 13, 2018
Bio-Rad Laboratories

Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb), a global leader of life science research and clinical diagnostic products, today announced the launch of two new chromatography media for process protein purification: CHT Ceramic Hydroxyapatite XT Media and Nuvia HP-Q Resin.

CHT Ceramic Hydroxyapatite XT (CHT XT) Mixed-Mode Media

CHT Ceramic Hydroxyapatite XT (CHT XT) Mixed-Mode Media was formulated in response to customers' need for a more robust and stable resin that can maintain the superior performance of CHT resins. CHT XT offers high resolution and efficient single-step clearance of aggregates and other impurities such as HCP, dsDNA, endotoxins, and leached Protein A. It can be used in applications such as purification of enzymes, monoclonal and polyclonal antibodies of various classes, antibody fragments, and bispecific antibodies; efficient isolation and purification of viruses and virus-like particles (VLPs); and, separation of supercoiled DNA from linear duplexes as well as single-stranded from double-stranded DNA.

Key benefits of CHT XT Media

  • Unique selectivity — binds by cation exchange and affinity interactions, unlike any unimodal resin
  • Cost efficiency — reusability improves economy of the process purification workflow
  • Time efficiency — can be used for single-step clearance of aggregates and other impurities
  • Broad chemical compatibility — is compatible with a wide range of chemicals

To learn more about CHT Ceramic Hydroxyapatite XT (CHT XT) Mixed-Mode Media, please visit bio-rad.com/CHT-XT.

Nuvia HP-Q Anion Exchange Resin

Nuvia HP-Q Anion Exchange Resin was introduced to fill customers’ need for a high-performance resin compatible with high-throughput (HTP) large biomolecule purification. It can be used for downstream purification of large molecules such as high molecular weight (HMW) plasma proteins IgA and IgM, viruses, VLPs, and PEGylated proteins.

Key benefits of Nuvia HP-Q Resin

  • Time efficiency and HTP compatibility — high flow rate compatibility (300 cm/hr) and fast mass transfer kinetics ensure purifications can be performed in less time
  • Cost efficiency — lifetime of more than 100 cycles without loss of dynamic binding capacity (DBC) allows repeated use
  • Mechanical stability — resin column holds up under the flow rates required for manufacturing-scale purification
  • High productivity — excellent DBC (>50 mg/ml) with optimized pore structure, spacer length, and ligand density improves productivity

To learn more about Nuvia HP-Q Anion Exchange Resin, please visit bio-rad.com/Nuvia HP-Q.

Both media will be on display at BioProcess International Conference & Exhibition in Boston, September 5–7. At the event Bio-Rad will also host daily Design of Experiment (DoE) Workshops in Booth 1617 to discuss best strategies for screening new resins and tools to facilitate experimental design. Highlights of DoE workshop include:

  • Introduction of new chromatography resins and best DoE practices
  • Discussion of new ChromLab 6.0 Software features
  • Exploration of how multivariable scouting with the NGC Chromatography System aids in DoE
  • Visualization of stain-free gels and western blots with the ChemiDoc MP Imaging System
  • Detection of impurities before and after purification with the Droplet Digital PCR System

To attend a DoE Booth Workshop, please visit bio-rad.com/BPIworkshop.

December 2018

Invisible Borders

An emerging appreciation for membraneless organelles and the liquid dynamics that shape them

Marketplace

Sponsored Product Updates

Rapid ELISA-Based Measurement Of Protein Phosphorylation
Rapid ELISA-Based Measurement Of Protein Phosphorylation
In this article, RayBiotech will present a study in which the phosphorylation of two proteins, STAT1 (Tyr701) and Mek1 (Ser217/221), is detected in response to various agonists. Data from the RayBio® Phosphorylation ELISA kits will be compared to traditional immunoblotting.
Protein Sample Quality Identification and Evaluation
Protein Sample Quality Identification and Evaluation
Checking the quality of your protein before and during your process gives you the highest chance of getting the consistent results. Learn how to evaluate the quality of your protein samples with this application note from NanoTemper!
Using CDD Vault to Manage Redbrick Molecular Ltd. Catalogues - A Case Study
Using CDD Vault to Manage Redbrick Molecular Ltd. Catalogues - A Case Study
Check out this case study to find out why Redbrick Molecular Ltd. chose CDD Vault as their database and informatics platform, and how they made use of the CDD Vault to implement a complex catalogue in a simple way.
New automated N-glycan profiling web app shaves days off of data interpretation for glycobiologists
New automated N-glycan profiling web app shaves days off of data interpretation for glycobiologists
The first automated, web-based application that enables routine use of enzymatic digestions to improve N-glycan analyses from New England Biolabs (NEB). This software not only saves precious times for glycobiologists who are more attuned to traditional methods, but also provides the most accurate interpretation of glycan enzymatic digestion data on the market.