GloMelt™ Thermal Shift Protein Stability Assay
A rapid and inexpensive fluorescence method for screening conditions that affect protein thermal stability, such as protein mutations, ligand binding, and buffer formulations (like pH, salts, detergents, and other additives).
Apr 16, 2018
A rapid and inexpensive fluorescence method for screening conditions that affect protein thermal stability, such as protein mutations, ligand binding, and buffer formulations (like pH, salts, detergents, and other additives).
GloMelt™ dye performs very well in high detergent concentrations, unlike SYPRO® Orange
GloMelt™ dye generates a strong signal because it is optimized for detection in the SYBR® Green channel of qPCR instruments
Great for high throughput assays, low reaction volumes and low protein concentrations
GloMelt™ dye tolerates DTT very well, unlike PROTEOSTAT® PTS dye
Can be combined with ROX to get very precise replicates in qPCR systems requiring ROX reference dye
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