drug development

High-Resolution Mass Spectrometry Solutions in Drug Discovery and Development

Electron activated dissociation (EAD) and the Zeno trap provide high sensitivity and certainty in mass spectrometry results.

Researchers analyzing protein-based drugs with mass spectrometry must handle challenges including analyte ion distribution over multiple charge states. The ZenoTOF 7600 system is a high-resolution mass spectrometry technology that pairs Zeno trap with electron activated dissociation (EAD) and allows scientists to accelerate drug discovery and development programs by identifying and localizing amino acid-specific post-translational modifications (PTMs) across all charge states. Additionally, scientists use this system to obtain highly descriptive fragment information and highly accurate positional confirmation; dramatically increase fragment ion coverage; and quickly and accurately produce intact and subunit results with confidence.

Explore this content pack by SCIEX to achieve

  • Comprehensive analysis and characterization of next generation biologics, including monoclonal antibodies
  • Enhanced product quality attribute investigation
  • Advanced protein therapeutic characterization
  • Comprehensive differentiation and localization of PTMs, including glycosylation, deamidation, and sulfation

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