Understanding hepatic drug metabolism is necessary to meet the strict safety-testing requirements for market approval of new products. Researchers typically need to use primary cryopreserved hepatocytes from a large number of donors to obtain a statistically significant result. However, pooled donor hepatocytes currently available on the market commonly suffer from increased lot-to-lot variability, while not being able to meet more specialized application needs.
Lonza’s patented manufacturing process ensures that the DonorPlex™ Hepatocytes exhibit improved phenotype reproducibility. Furthermore, a proprietary algorithm that predicts yield, viability and functional phenotype prior to manufacture ensures individual customer specifications are met.
"Drug discovery scientists require access to high-quality hepatocytes that can deliver consistent and dependable results to expedite new product approval," said Dr. Maureen Bunger, Product Manager for ADME-Tox Solutions at Lonza. "Lonza’s DonorPlex™ Hepatocytes have been designed to do just that. Our patented pooling procedure, in combination with our predictive algorithm, means we can...
The DonorPlex™ Hepatocytes offer a large, comprehensive inventory of cryopreserved single donor suspension hepatocytes, which include a range of 10-, 20- and 50-donor gender-specific and mixed-gender lots.