A new study overthrows a long-held theory on how HIV finds its way into host cells. Rather than fusing directly with the host cell membrane, the virus is first engulfed by it to form a vesicle that releases its contents into the cytoplasm, a study published tomorrow (May 1) in __Cell__ reports. linkurl:The findings;http://www.cell.com/abstract/S0092-8674(09)00268-2 may suggest other therapeutic avenues for targeting HIV, the researchers say.
"This is such an extensive and thorough paper that I think people are going to accept this as the dominant mode of viral entry" for HIV, said linkurl:Robert Blumenthal,;http://ccr.cancer.gov/Staff/staff.asp?profileid=5748 head of the Membrane Structure and Function Section at the National Cancer Institute in Frederick,...
membrane (red) and content (green) markers
migrates toward the cell nucleus and releases
its contents into the cytosol by fusing with
the endosomal membrane.
Image: Gregory Melikyan & Yuri Kim
Drawing: Norair Melikyan Images
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