A new twist on nanoparticle behavior

Researchers hoping to develop linkurl:nanoparticles;http://www.the-scientist.com/article/display/15659/ as medicines or carriers of therapeutic molecules have much more to worry about than the type of material they plan on miniaturizing, according to a linkurl:study;http://www.pnas.org/cgi/doi/10.1073/pnas.0805135105 in this week's issue of the __Proceedings of the National Academy of Science__. Researchers in Ireland found that the corona, or cloud of proteins and other biomolecules that adher

Bob Grant
Bob Grant

Bob Grant is Editor in Chief of The Scientist, where he started in 2007 as a Staff Writer.

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Sep 22, 2008
Researchers hoping to develop linkurl:nanoparticles;http://www.the-scientist.com/article/display/15659/ as medicines or carriers of therapeutic molecules have much more to worry about than the type of material they plan on miniaturizing, according to a linkurl:study;http://www.pnas.org/cgi/doi/10.1073/pnas.0805135105 in this week's issue of the __Proceedings of the National Academy of Science__. Researchers in Ireland found that the corona, or cloud of proteins and other biomolecules that adheres to a nanoparticle immersed in biological media (in this study human blood plasma), changes depending on the size of the nanoparticle and the charge on its surface. That, in turn, can affect the particles' therapeutic action in the body. Nanotechnology is "an enormously powerful tool, but we need to know how to control it," linkurl:Kenneth Dawson,;http://www.ucd.ie/chem/dawson/index.html a University College Dublin physical chemist and the study's senior author, told __The Scientist__. "We have to look at what's happening at the surface of these materials rather than just the materials themselves. It's...

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