Whether coinfection by multiple viruses poses a greater threat to humans than infection by Zika alone is unclear, researchers say.
As ABC News reported, when the researchers exposed 48 mosquitoes to all three viruses, 92 percent of the mosquitos tested positive for them all somewhere in the body, and six of the 48 mosquitoes (12.5 percent) had all three viruses in their saliva.
“Based on what I know as a virologist, epidemiologist, and entomologist, I thought that the viruses would either compete or enhance each other in some way,” said Greg Ebel, director of CSU’s Arthropod-borne and Infectious Diseases Laboratory and co-author of the study, in a press release. “We didn’t see much evidence of either one of these things.”
Study author Claudia Rückert said in the release that triple infections are likely rare occurrences, but noted that “dual infections in humans, however, are fairly common, or more common than we would have thought.” Studies have produced conflicting results about whether multiple infections are worse than one.
William Schaffner, an infectious disease expert at Vanderbilt University Medical Center, told ABC News that coinfection was a “fascinating notion” but that it would be important to detect it in the wild.
Complicating diagnoses of human coinfection is the fact that blood tests do not distinguish well between the different viruses, Schaffner told ABC. “That’s part of the difficulty if you use the blood test, the viruses are sufficiently similar so that the blood test are nonspecific and you’re not sure.” Furthermore, the diseases have similar symptoms.
“Depending on what diagnostics are used, and depending on what the clinicians think, they might not notice there's another virus,” Rückert said in the release. “It could definitely lead to misinterpretation of disease severity.”