Menu

An Obesity-Cancer Link?

Why obese individual are more likely to get cancer could be partly explained by a gene that activates both pathways.

Nov 22, 2011
Edyta Zielinska

FLICKR, JILL A. BROWN

A gene variant found in some 30 percent of type 2 diabetics can inhibit the action of p53—the gatekeeper of the cell cycle and one of the most commonly mutated genes across cancers, according to research from Lund University Diabetes Centre.

The gene TCF normally protects insulin-producing ß-cells from damage due to excess sugar exposure. But a number of diabetics have a variant of this gene that impairs the cell’s ability to secrete insulin, eventually killing the ß-cell, thus leading to diabetes.

In a study published in the journal Human Molecular Genetics, the researchers looked for the molecules that interacted with the TCF variant and noticed that one of them was p53. When they blocked TCF in the cell, the levels of p53 went up, demonstrating a link between the cancer-related gene and TCF.  When TCF isn’t blocked, p53 expression is suppressed, rendering cells much more likely to accumulate mutations during division that could lead to cancer.

July 2019

On Target

Researchers strive to make individualized medicine a reality

Marketplace

Sponsored Product Updates

IDT and Washington University join forces to increase access to the latest NGS technologies
IDT and Washington University join forces to increase access to the latest NGS technologies
As part of its commitment to advocate for the genomics age, Integrated DNA Technologies (IDT) aims to lower the barriers to access the latest NGS technologies.
Bio-Rad Launches Bio-Plex Pro Human Immunotherapy Panel 20-plex Multiplex Assay, a targeted tool for researching signaling networks in Immunotherapy Research
Bio-Rad Launches Bio-Plex Pro Human Immunotherapy Panel 20-plex Multiplex Assay, a targeted tool for researching signaling networks in Immunotherapy Research
Bio-Rad Laboratories, Inc. (NYSE: BIO and BIOb) July 15, 2019 announced the launch of its Bio-Plex Pro Human Immunotherapy Panel 20-plex, a multiplex immunoassay that offers a targeted approach for Immunotherapy Research.
DeNovoMAX - NRGene's new genomics tool to meet a major agbio need:
DeNovoMAX - NRGene's new genomics tool to meet a major agbio need:
NRGene has launched a new product that aims to empower breeding and maximize agricultural yield as part of the Denovo assembly product suite offered by the company.
Overcoming the Efficiency Challenge in Clinical NGS
Overcoming the Efficiency Challenge in Clinical NGS
Download this white paper to see how an ECS lab serving a network of more than 10,000 healthcare providers integrated QIAGEN Clinical Insight (QCI) Interpret to significantly reduce manual variant curation efforts and increase workflow efficiency by 80%!