A microbiologist who changed science's understanding of cell linkurl:signal transduction;http://www.the-scientist.com/article/display/17076/ and linkurl:protein structure;http://www.the-scientist.com/article/display/15800/ has won the 2008 Kyoto Prize in linkurl:Basic Science.;http://www.kyotoprize.org/ linkurl:Anthony Pawson,;http://pawsonlab.mshri.on.ca/ a British-born scientist who now lives and works in Canada, received the award for "his proposal and proof of the concept of adapter molecules, which has established one of the basic paradigms in intracellular signal transduction and contributed significantly to the subsequent development of the life sciences," according to the linkurl:Inamori Foundation,;http://www.inamori-f.or.jp/index_e.html which administers the prize. "I'm sort of amazed," Pawson, one of two Canada-based researchers to win this year's prize, said. "It's a wonderful prize." Pawson, who is now an investigator at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital and a professor at the University of Toronto, is best know for his 1986 linkurl:discovery;http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=367222 of the Src homology 2 (SH2) domain, which is essential in cell proliferation, metabolism, and cell-cell communication. Pawson's discovery...

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