Menu

Caloric Restriction Slows Signs of Aging in Humans

Findings from a randomized, controlled trial finds that reducing food intake decreases metabolism and reduces oxidative damage to tissues and cells.

Mar 26, 2018
Diana Kwon

PIXABAY, MIMZY

Studies in various animals, including rodents and monkeys, have reported that caloric restriction can extend their lifespans. Findings from a two-year, randomized, controlled trial with human participants, published last week (March 22) in Cell Metabolism, suggest that cutting down on calories may also be able to prolong the lives of people.

To investigate the effects of reducing food intake, Leanne Redman, an endocrinologist at the Pennington Biomedical Research Center at Louisiana State University, and her colleagues enrolled 53 healthy men and women between the ages of 21 and 50 and split them into two groups—one group reduced their caloric intake by 15 percent over two years, and the other remained on a regular diet.

The team found that the people who ate a restricted diet lost an average of around 9 kilograms and experienced a 10-percent drop in their resting metabolic rates. When the researchers examined the participants’ blood, they also found a reduction in markers of oxidative stress in those who cut down on calories. “After two years, the lower rate of metabolism and level of calorie restriction was linked to a reduction in oxidative damage to cells and tissues,” Redman tells Wired.

“[I]f by-products of metabolism accelerate aging processes, calorie restriction sustained over several years may help to decrease risk for chronic disease and prolong life,” Redman says in a statement.

See “Running on Empty

This study was part of a larger, multi-center investigation of caloric restriction in humans, the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) trial. Luigi Fontana, an internist who ran a CALERIE investigation at Washington University in St. Louis, says that a slower metabolism and reduced oxidative stress will not necessarily lead to a longer life. “You can have a low resting metabolic rate because you’re dying of starvation,” he tells Wired. “Does that make it a biomarker of longevity? No. You can be calorie restricted by eating half a hamburger and a few fries each day but will you live longer? No, you will die of malnutrition.”

December 2018

Invisible Borders

An emerging appreciation for membraneless organelles and the liquid dynamics that shape them

Marketplace

Sponsored Product Updates

Rapid ELISA-Based Measurement Of Protein Phosphorylation
Rapid ELISA-Based Measurement Of Protein Phosphorylation
In this article, RayBiotech will present a study in which the phosphorylation of two proteins, STAT1 (Tyr701) and Mek1 (Ser217/221), is detected in response to various agonists. Data from the RayBio® Phosphorylation ELISA kits will be compared to traditional immunoblotting.
Protein Sample Quality Identification and Evaluation
Protein Sample Quality Identification and Evaluation
Checking the quality of your protein before and during your process gives you the highest chance of getting the consistent results. Learn how to evaluate the quality of your protein samples with this application note from NanoTemper!
Using CDD Vault to Manage Redbrick Molecular Ltd. Catalogues - A Case Study
Using CDD Vault to Manage Redbrick Molecular Ltd. Catalogues - A Case Study
Check out this case study to find out why Redbrick Molecular Ltd. chose CDD Vault as their database and informatics platform, and how they made use of the CDD Vault to implement a complex catalogue in a simple way.
New automated N-glycan profiling web app shaves days off of data interpretation for glycobiologists
New automated N-glycan profiling web app shaves days off of data interpretation for glycobiologists
The first automated, web-based application that enables routine use of enzymatic digestions to improve N-glycan analyses from New England Biolabs (NEB). This software not only saves precious times for glycobiologists who are more attuned to traditional methods, but also provides the most accurate interpretation of glycan enzymatic digestion data on the market.