Cancer genomes sequenced

Scientists have charted the most complete cancer genomes to date, according to two studies published in Nature this week, providing a catalog of some 90% of all the somatic mutations in melanoma and a type of lung cancer, as well as a starting point for identifying potentially causal mutations common to these types of cancer. Cross section of a human lung with cancerImage: Wikimedia commons"For the first time we have a really quite comprehensive view of two different common tumor types," said l

Jef Akst
Jef Akst

Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf...

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Dec 15, 2009
Scientists have charted the most complete cancer genomes to date, according to two studies published in Nature this week, providing a catalog of some 90% of all the somatic mutations in melanoma and a type of lung cancer, as well as a starting point for identifying potentially causal mutations common to these types of cancer.
Cross section of a human lung with cancer
Image: Wikimedia commons
"For the first time we have a really quite comprehensive view of two different common tumor types," said linkurl:Bert Vogelstein;http://www.hopkinsmedicine.org/pharmacology/research/vogelstein.html of Johns Hopkins Medicine, who was not involved in the research. "That information will form the foundation for subsequent studies." Previously, scientists studying cancer genomes had identified a handful of so-called driver mutations -- those that have a causative effect on the cancerous growth. But these two papers are the first to also analyze the noncoding regions of the genome, which may also contain...




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