Three of 13 established esophageal adenocarcinoma (EAC) cell lines are not EAC after all. Instead, the lines -- which have led to two clinical trials, more than 100 publications and 11 US patents -- represent three different cancer types altogether, a study published online today (January 14) in the Journal of the National Cancer Institute (JNCI) found.
"It's a startling and somewhat alarming finding that the cell lines we thought represented specific entities actually do not," said cancer biologist linkurl:Ezra Cohen,;http://www.uchospitals.edu/physicians/ezra-cohen.html who was heading up a clinical trial based partially on experiments conducted with one of the three contaminated EAC cell lines at the time these results became known to the field a few months ago. "If you're going to do studies focusing on [a specific] disease, you probably want to do...
differentiated squamous cell carcinoma
in the excisional biopsy specimen
Image: Wikimedia commons
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