Menu

Centipede Venom Tops Morphine

The substance targets the same ion channel that's mutated in people who don't feel pain.

Oct 1, 2013
Kerry Grens

WIKIMEDIA, YASUNORI KOIDEAn alteration in a sodium ion channel can leave people completely indifferent to pain, making the channel an appealing target for analgesic development. In a report published in the Proceedings of the National Academy of Sciences this week (September 30), researchers characterize a newly discovered component of centipede venom that inhibits this particular sodium channel, NaV1.7, and works even better than morphine to dampen pain in rodents. “Centipedes worked out hundreds of millions of years ago the easiest way to catch prey was to paralyze them by blocking their NaV channel,” Glenn King, one of the authors of the study, told ABC. “We're just lucky that of the nine NaV channels in humans, it hit the one we were after.”

King, a researcher at the University of Queensland, said that other attempts to bind the NaV1.7 channel blocked other sodium channels and produced untoward effects. But King and his colleagues found that the venom-derived peptide was much more selective for 1.7 than for other sodium ion channels. And it showed no negative impacts on heart rate, blood pressure, or motor function. The centipede peptide was also more potent than morphine in a chemically induced pain assay in mice, and was just as effective as the narcotic in relieving pain induced by acid or heat.

Of course, a number of studies will have to validate the safety and efficacy of the drug before it could be used to treat pain in humans. Already, several venom-derived peptides have been developed for human therapy. King envisions that centipede venom could be useful in treating chronic pain. According to The Australian, it will be critical to “get the dose right” so that people could still feel a burn, for example. “But they wouldn’t have this ongoing pain, often resulting from a nerve injury or something that just hasn’t been dampened down by the brain,” King told The Australian.

November 2018

Intelligent Science

Wrapping our heads around human smarts

Marketplace

Sponsored Product Updates

LGC announces new, integrated, global portfolio brand, Biosearch Technologies, representing genomic tools for mission critical customer applications

LGC announces new, integrated, global portfolio brand, Biosearch Technologies, representing genomic tools for mission critical customer applications

LGC’s Genomics division announced it is transforming its branding under LGC, Biosearch Technologies, a unified portfolio brand integrating optimised genomic analysis technologies and tools to accelerate scientific outcomes.

DefiniGEN licenses CRISPR-Cas9 gene editing technology from Broad Institute to develop cell models for optimized metabolic disease drug development

DefiniGEN licenses CRISPR-Cas9 gene editing technology from Broad Institute to develop cell models for optimized metabolic disease drug development

DefiniGEN Ltd are pleased to announce the commercial licensing of CRISPR-Cas9 gene-editing technology from Broad Institute of MIT and Harvard in the USA, to develop human cell disease models to support preclinical metabolic disease therapeutic programmes.

Thermo Fisher Scientific: Freezers for Biological Samples

Thermo Fisher Scientific: Freezers for Biological Samples

Fluctuations in temperature can reduce the efficacy, decompose, or shorten the shelf life of biologics. Therefore, it is important to store biologics at the right temperature using standardized protocols.