I've officially heard my favorite one-liner here at the Keystone symposium on the molecular basis for biological membrane organization. In her presentation on the molecular link between polycystic defects such as retinopathies and linkurl:polycystic kidney disease,;http://www.the-scientist.com/article/display/14662/ Angela Wandinger-Ness of the University of New Mexico offered this gem: "There is a connection between seeing and peeing." After the giggles subsided, linkurl:Wandinger-Ness;http://hsc.unm.edu/research/FacultyProfiles/index.cfm?m=main.faculty&unique_id=685BABBDC47011E7C89FE814E6CAC6AB went on to describe her research on the commonality of linkurl:primary cilia;http://www.the-scientist.com/article/display/14976/ malfunction in such diseases. She said that problems with the localization of signaling proteins to the ciliary membranes and the subsequently disrupted membrane trafficking may be the key to problems with kidney function, vision, and other sensory pathways. In vision, for example, mutations in the ciliary protein rhodopsin - which functions in initiating light sensing and photoreceptor formation - may lead to developmental disorders resulting in cell death and degeneration of the retina. Mutations in polycystic kidney disease...
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